[HTML][HTML] Ultraviolet radiation-induced non-melanoma skin cancer: Regulation of DNA damage repair and inflammation
IY Kim, YY He - Genes & diseases, 2014 - Elsevier
Exposure to ultraviolet (UV) radiation is associated with approximately 65% of melanoma
cases, and 90% of non-melanoma skin cancers (NMSC), including basal cell carcinoma …
cases, and 90% of non-melanoma skin cancers (NMSC), including basal cell carcinoma …
UV-induced molecular signaling differences in melanoma and non-melanoma skin cancer
F Liu-Smith, J Jia, Y Zheng - Ultraviolet light in human health, diseases …, 2017 - Springer
There are three major types of skin cancer: melanoma, basal cell carcinoma (BCC) and
squamous cell carcinoma (SCC). BCC and SCC are often referred to as non-melanoma skin …
squamous cell carcinoma (SCC). BCC and SCC are often referred to as non-melanoma skin …
Emerging perspective: role of increased ROS and redox imbalance in skin carcinogenesis
D **an, R Lai, J Song, X **ong… - Oxidative medicine and …, 2019 - Wiley Online Library
Strategies to battle malignant tumors have always been a dynamic research endeavour.
Although various vehicles (eg, chemotherapeutic therapy, radiotherapy, surgical resection …
Although various vehicles (eg, chemotherapeutic therapy, radiotherapy, surgical resection …
The PTEN conundrum: how to target PTEN-deficient prostate cancer
DJ Turnham, N Bullock, MS Dass, JN Staffurth… - Cells, 2020 - mdpi.com
Loss of the tumor suppressor phosphatase and tensin homologue deleted on chromosome
10 (PTEN), which negatively regulates the PI3K–AKT–mTOR pathway, is strongly linked to …
10 (PTEN), which negatively regulates the PI3K–AKT–mTOR pathway, is strongly linked to …
PTEN in DNA damage repair
The ability of DNA repair in a cell is vital to its genomic integrity and thus to the normal
functioning of an organism. Phosphatase and tensin homolog (PTEN) is a well-established …
functioning of an organism. Phosphatase and tensin homolog (PTEN) is a well-established …
MC1R is a potent regulator of PTEN after UV exposure in melanocytes
The individuals carrying melanocortin-1 receptor (MC1R) variants, especially those
associated with red hair color, fair skin, and poor tanning ability (RHC trait), are more prone …
associated with red hair color, fair skin, and poor tanning ability (RHC trait), are more prone …
SIRT6 promotes COX-2 expression and acts as an oncogene in skin cancer
SIRT6 is a SIR2 family member that regulates multiple molecular pathways involved in
metabolism, genomic stability, and aging. It has been proposed previously that SIRT6 is a …
metabolism, genomic stability, and aging. It has been proposed previously that SIRT6 is a …
The role of altered nucleotide excision repair and UVB-induced DNA damage in melanomagenesis
UVB radiation is the most mutagenic component of the UV spectrum that reaches the earth's
surface and causes the development of DNA damage in the form of cyclobutane pyrimidine …
surface and causes the development of DNA damage in the form of cyclobutane pyrimidine …
[HTML][HTML] Ultraviolet radiation-mediated development of cutaneous melanoma: An update
Ultraviolet (UV) light is absorbed by nucleic acids, proteins or other endogenous
chromophores, such as porphyrins, flavins and melanin, triggering biological processes in …
chromophores, such as porphyrins, flavins and melanin, triggering biological processes in …
PTEN methylation by NSD2 controls cellular sensitivity to DNA damage
The function of PTEN in the cytoplasm largely depends on its lipid-phosphatase activity,
though which it antagonizes the PI3K–AKT oncogenic pathway. However, molecular …
though which it antagonizes the PI3K–AKT oncogenic pathway. However, molecular …