Diverse functions of cytochrome c in cell death and disease

Z Zhou, T Arroum, X Luo, R Kang, YJ Lee… - Cell Death & …, 2024 - nature.com
The redox-active protein cytochrome c is a highly positively charged hemoglobin that
regulates cell fate decisions of life and death. Under normal physiological conditions …

Stroke in the time of circadian medicine

P Mergenthaler, JS Balami, AA Neuhaus… - Circulation …, 2024 - ahajournals.org
Time-of-day significantly influences the severity and incidence of stroke. Evidence has
emerged not only for circadian governance over stroke risk factors, but also for important …

[HTML][HTML] Integrated network toxicology, molecular docking, and in vivo experiments to elucidate molecular mechanism of aflatoxin B1 hepatotoxicity

B Ge, K Yan, R Sang, W Wang, X Liu, M Yu… - Ecotoxicology and …, 2024 - Elsevier
Due to the rise in temperature and sea level caused by climate change, the detection rate of
aflatoxin B1 (AFB1) in food crops has increased dramatically, and the frequency and severity …

PI3K/AKT signaling and neuroprotection in ischemic stroke: molecular mechanisms and therapeutic perspectives

T Liu, X Li, X Zhou, W Chen, A Wen… - Neural regeneration …, 2025 - journals.lww.com
It has been reported that the PI3K/AKT signaling pathway plays a key role in the
pathogenesis of ischemic stroke. As a result, the development of drugs targeting the …

Shenfu injection: a review of pharmacological effects on cardiovascular diseases

FF Xu, XF **e, HY Hu, RS Tong, C Peng - Frontiers in Pharmacology, 2024 - frontiersin.org
Shenfu injection (SFI), composed of ginseng and aconite, is a Chinese patent developed
from the classic traditional prescription Shenfu Decoction created more than 700 years ago …

Apoptosis-induced translocation of nesprin-2 from the nuclear envelope to mitochondria is associated with mitochondrial dysfunction

H Zohar, L Lindenboim, O Gozlan, GG Gundersen… - Nucleus, 2024 - Taylor & Francis
Accumulating evidence suggests that the nuclear envelope (NE) is not just a target, but also
a mediator of apoptosis. We showed recently that the NE protein nesprin-2 has pro-apoptotic …

Cold atmospheric plasma attenuates skin cancer via ROS induced apoptosis

C Liu, J Zha, T Sun, L Kong, X Zhang, D Wang… - Molecular Biology …, 2024 - Springer
Background Cold atmospheric plasma (CAP) has been widely used in biomedical research,
especially in vitro cancer therapy. Cutaneous squamous cell carcinoma (CSCC) is a …

[HTML][HTML] A natural acylphloroglucinol exerts anti-erythroleukemia effects via targeting STAT3 and p38-MAPK, and inhibiting PI3K/AKT/mTOR signaling pathway

JR Song, ZP Niu, K Yang, L Wang, YB Huang… - Biomedicine & …, 2024 - Elsevier
Erythroleukemia, a subtype of acute myeloid leukemia (AML), is a life-threatening
malignancy that affects the blood and bone marrow. Despite the availability of clinical …

[HTML][HTML] Potential Anticancer Effects of Isoflavone Prunetin and Prunetin Glycoside on Apoptosis Mechanisms

SH Jeong, HH Kim, MY Park, PB Bhosale… - International Journal of …, 2024 - mdpi.com
Cancer is a deadly disease caused by cells that deviate from the normal differentiation and
proliferation behaviors and continue to multiply. There is still no definitive cure, and many …

Targeting programmed cell death in diabetic kidney disease: from molecular mechanisms to pharmacotherapy

F Liu, Z Yang, J Li, T Wu, X Li, L Zhao, W Wang… - Molecular …, 2024 - Springer
Diabetic kidney disease (DKD), one of the most prevalent microvascular complications of
diabetes, arises from dysregulated glucose and lipid metabolism induced by hyperglycemia …