Genetic variation in the immunoglobulin heavy chain locus shapes the human antibody repertoire
OL Rodriguez, Y Safonova, CA Silver, K Shields… - Nature …, 2023 - nature.com
Variation in the antibody response has been linked to differential outcomes in disease, and
suboptimal vaccine and therapeutic responsiveness, the determinants of which have not …
suboptimal vaccine and therapeutic responsiveness, the determinants of which have not …
Evolutionary patterns and functional effects of 3D chromatin structures in butterflies with extensive genome rearrangements
B Zhou, P Hu, G Liu, Z Chang, Z Dong, Z Li… - Nature …, 2024 - nature.com
Chromosome rearrangements may distort 3D chromatin architectures and thus change gene
regulation, yet how 3D chromatin structures evolve in insects is largely unknown. Here, we …
regulation, yet how 3D chromatin structures evolve in insects is largely unknown. Here, we …
Locus architecture and RAG scanning determine antibody diversity
AL Kenter, S Priyadarshi, EB Drake - Trends in immunology, 2023 - cell.com
Diverse mammalian antibody repertoires are produced via distant genomic contacts
involving immunoglobulin Igh variable (V), diversity (D), and joining (J) gene segments and …
involving immunoglobulin Igh variable (V), diversity (D), and joining (J) gene segments and …
Locus folding mechanisms determine modes of antigen receptor gene assembly
The dynamic folding of genomes regulates numerous biological processes, including
antigen receptor (AgR) gene assembly. We show that, unlike other AgR loci, homotypic …
antigen receptor (AgR) gene assembly. We show that, unlike other AgR loci, homotypic …
Addressing technical pitfalls in pursuit of molecular factors that mediate immunoglobulin gene regulation
E Engelbrecht, OL Rodriguez… - The Journal of …, 2024 - journals.aai.org
The expressed Ab repertoire is a critical determinant of immune-related phenotypes. Ab-
encoding transcripts are distinct from other expressed genes because they are transcribed …
encoding transcripts are distinct from other expressed genes because they are transcribed …
C Bassing, E Oltz, B Allyn, K Hayer, C Oyeniran… - bioRxiv, 2024 - biorxiv.org
Cohesin-mediated chromosome loo** regulates diverse processes, including antigen
receptor (AgR) gene assembly by V (D) J recombination. To understand mechanisms that …
receptor (AgR) gene assembly by V (D) J recombination. To understand mechanisms that …
Alternative DNA structures in hematopoiesis and adaptive immunity.
Besides the canonical B-form, DNA also adopts alternative non-B form conformations which
are highly conserved in all domains of life. While extensive research over decades has …
are highly conserved in all domains of life. While extensive research over decades has …