The “epigenetics” concept was first described in 1942. Thus far, chemical modifications on
histones, DNA, and RNA have emerged as three important building blocks of epigenetic …

Gliomas are the most common malignant primary brain tumors, of which glioblastoma is the
most malignant form (WHO grade IV), and notorious for treatment resistance. Over the last …

As one of the most abundant and well-studied epigenetic modifications, DNA methylation
plays an essential role in normal development and cellular biology. Global alterations to the …

Hydroxymethylcytosine (5hmC) is an important epigenetic mark that regulates gene
expression. Charting the landscape of 5hmC in human tissues is fundamental to …

Histone lysine‐specific demethylase 1 (LSD1) is the first discovered and reported histone
demethylase by Dr. Shi Yang's group in 2004. It is classified as a member of amine oxidase …

Kee** a balance between DNA methylation and demethylation balance is central for
mammalian development and cell function, particularly in the hematopoietic system. In …

Simple Summary Maintenance of telomeres is a fundamental step in human carcinogenesis
and is primarily regulated by telomerase and the human telomerase reverse transcriptase …

Recent discoveries have led to the development of novel ideas and techniques that have
helped elucidate the correlation between epigenetics and tumor biology. Nowadays, the …

Background Colorectal cancer (CRC) is the third most commonly diagnosed human
malignancy worldwide. Upregulation of inhibitory immune checkpoints by tumor-infiltrating …

Abstract Background Glioma stem cells (GSCs) are a subpopulation of stem-like cells that
contribute to glioblastoma (GBM) aggressiveness, recurrence, and resistance to radiation …