Excessive alcohol consumption is a global healthcare problem. The liver sustains the
greatest degree of tissue injury by heavy drinking because it is the primary site of ethanol …

Excessive alcohol consumption is a global healthcare problem with enormous social,
economic, and clinical consequences. While chronic, heavy alcohol consumption causes …

Extracellular vesicles (EVs), membrane-bound vesicles that are naturally released by cells,
have emerged as new therapeutic opportunities. EVs, particularly exosomes and …

Acetaldehyde dehydrogenase 2 (ALDH2) is the key enzyme responsible for metabolism of
the alcohol metabolite acetaldehyde in the liver. In addition to conversion of the …

Liver injury is a characteristic feature of human immunodeficiency virus (HIV) infection,
which is the second most common cause of mortality in HIV-infected patients. Now it is …

Common liver tissue damage is mainly due to the accumulation of toxic aldehydes in lipid
peroxidation under oxidative stress. Cumulative toxic aldehydes in the liver can be …

Aldehyde dehydrogenase 2 (ALDH2) is a key enzyme of alcohol metabolism and it is
involved in the cellular mechanism of alcohol liver disease. ALDH2 gene mutations exist in …

Introduction Obesity during pregnancy increases the risk for maternal complications like
gestational diabetes, preeclampsia, and maternal inflammation. Maternal obesity also …

Communication between dying and neighbouring cells is vital to ensure appropriate
processes such as tissue repair or inflammation are initiated in response to cell death. As a …

Background Alcohol consumption exacerbates the pathogenesis of hepatitis C virus (HCV)
infection and worsens disease outcomes. The exact reasons are not clear yet, but they might …