[HTML][HTML] The regulation of JAKs in cytokine signaling and its breakdown in disease
The JAK–STAT signal transduction pathway is responsible for mediating signals of over fifty
cytokines, growth factors and hormones. Signaling through the JAK–STAT pathway is …
cytokines, growth factors and hormones. Signaling through the JAK–STAT pathway is …
Role of non receptor tyrosine kinases in hematological malignances and its targeting by natural products
Tyrosine kinases belong to a family of enzymes that mediate the movement of the phosphate
group to tyrosine residues of target protein, thus transmitting signals from the cell surface to …
group to tyrosine residues of target protein, thus transmitting signals from the cell surface to …
The genomic landscape of pediatric and young adult T-lineage acute lymphoblastic leukemia
Genetic alterations that activate NOTCH1 signaling and T cell transcription factors, coupled
with inactivation of the INK4/ARF tumor suppressors, are hallmarks of T-lineage acute …
with inactivation of the INK4/ARF tumor suppressors, are hallmarks of T-lineage acute …
Pharmacological modulation of the crosstalk between aberrant Janus kinase signaling and epigenetic modifiers of the histone deacetylase family to treat cancer
Hyperactivated Janus kinase (JAK) signaling is an appreciated drug target in human
cancers. Numerous mutant JAK molecules as well as inherent and acquired drug resistance …
cancers. Numerous mutant JAK molecules as well as inherent and acquired drug resistance …
[HTML][HTML] IL-7R-mediated signaling in T-cell acute lymphoblastic leukemia: An update
Abstract Interleukin 7 (IL-7) and its receptor (IL-7R, a heterodimer of IL-7Rα and γc) are
essential for normal lymphoid development. In their absence, severe combined …
essential for normal lymphoid development. In their absence, severe combined …
Working and safety profiles of JAK/STAT signaling inhibitors. Are these small molecules also smart?
E Favoino, M Prete, G Catacchio, P Ruscitti… - Autoimmunity …, 2021 - Elsevier
The Janus kinase (JAK)/signal transducers and activators of transcription (STAT) pathway is
an important intracellular route through which many different extracellular soluble …
an important intracellular route through which many different extracellular soluble …
Comprehensive analysis of transcriptome variation uncovers known and novel driver events in T-cell acute lymphoblastic leukemia
RNA-seq is a promising technology to re-sequence protein coding genes for the
identification of single nucleotide variants (SNV), while simultaneously obtaining information …
identification of single nucleotide variants (SNV), while simultaneously obtaining information …
Aberrant signaling pathways in T-cell acute lymphoblastic leukemia
D Bongiovanni, V Saccomani, E Piovan - International journal of …, 2017 - mdpi.com
T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive disease caused by the
malignant transformation of immature progenitors primed towards T-cell development …
malignant transformation of immature progenitors primed towards T-cell development …
Novel activating STAT5B mutations as putative drivers of T-cell acute lymphoblastic leukemia
STAT5 has an important role in many hematologic malignancies, but constitutive activation
is often a secondary event. 1 Mutations to STAT5B and their functional significance were …
is often a secondary event. 1 Mutations to STAT5B and their functional significance were …
Development of selective covalent Janus kinase 3 inhibitors
L Tan, K Akahane, R McNally… - Journal of medicinal …, 2015 - ACS Publications
The Janus kinases (JAKs) and their downstream effectors, signal transducer and activator of
transcription proteins (STATs), form a critical immune cell signaling circuit, which is of …
transcription proteins (STATs), form a critical immune cell signaling circuit, which is of …