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[HTML][HTML] Natural and bioinspired excipients for dry powder inhalation formulations
Pulmonary drug delivery can have several advantages over other administration routes, in
particular when using dry powder formulations. Such dry powder inhalation formulations …
particular when using dry powder formulations. Such dry powder inhalation formulations …
Excipients for Novel Inhaled Dosage Forms: An Overview
Pulmonary drug delivery is a form of local targeting to the lungs in patients with respiratory
disorders like cystic fibrosis, pulmonary arterial hypertension (PAH), asthma, chronic …
disorders like cystic fibrosis, pulmonary arterial hypertension (PAH), asthma, chronic …
Inhaled deep eutectic solvent based-nanoemulsion of pirfenidone in idiopathic pulmonary fibrosis
Pirfenidone (PRF), the first FDA-approved drug to treat idiopathic pulmonary fibrosis (IPF)
and formulated as an oral dosage form, has many side effects. To enhance the therapeutic …
and formulated as an oral dosage form, has many side effects. To enhance the therapeutic …
Preparation of orodispersible tablets of bosentan using xylitol and menthol as dissolution enhancers
Bosentan is a drug used to treat pulmonary hypertension via dual endothelial receptor
antagonism. Bosentan has a restricted oral bioavailability, a problem that's mostly due to …
antagonism. Bosentan has a restricted oral bioavailability, a problem that's mostly due to …
Customizable resveratrol spray-dried micro-composites for inhalation as a promising contender for treatment of idiopathic pulmonary fibrosis
The past decades have witnessed tremendous expansion in utilization of plant-derived
medicines as resveratrol (RES) in treating several diseases like idiopathic pulmonary …
medicines as resveratrol (RES) in treating several diseases like idiopathic pulmonary …
In vivo pharmacokinetic and pharmacodynamic study of inhalable pirfenidone microparticles prepared via high-energy bead milling
Purpose Pirfenidone (PRF) is the first FDA-approved active pharmaceutical ingredient for
the treatment of idiopathic pulmonary fibrosis (IPF). However, it has severe adverse effects …
the treatment of idiopathic pulmonary fibrosis (IPF). However, it has severe adverse effects …
[HTML][HTML] Preparation and in vivo evaluation of a lidocaine self-nanoemulsifying ointment with glycerol monostearate for local delivery
Lidocaine, a commonly used local anesthetic, has recently been developed into a number of
ointment products to treat hemorrhoids. This study examined its efficient delivery to the …
ointment products to treat hemorrhoids. This study examined its efficient delivery to the …
Development of spray-dried N-acetylcysteine dry powder for inhalation
N-acetylcysteine (NAC) has both antioxidant and immunomodulatory activities and has been
used as adjuvant therapy in several viral infections. Recently, NAC attracted attention for its …
used as adjuvant therapy in several viral infections. Recently, NAC attracted attention for its …
High energy ball milling vs. nano spray drying in the development of supersaturated systems loaded with bosentan
A Krupa, F Danede, D Majda, A Węgrzyn… - European Journal of …, 2023 - Elsevier
In this study, high energy ball milling and nano spray drying were used to prepare
amorphous solid dispersions of bosentan in copovidone for the first time. In particular, the …
amorphous solid dispersions of bosentan in copovidone for the first time. In particular, the …
[HTML][HTML] Co-spray dried nafamostat mesylate with lecithin and mannitol as respirable microparticles for targeted pulmonary delivery: pharmacokinetics and lung …
Coronavirus disease 2019 (COVID-19), caused by a new strain of coronavirus called severe
acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is spreading rapidly worldwide …
acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is spreading rapidly worldwide …