Mutations in the leucine‐rich repeat kinase 2 (LRRK 2)‐encoding gene are the most
common cause of monogenic Parkinson's disease. The identification of LRRK 2 …

Protein-protein interactions (PPIs) are a key component of the subcellular molecular
networks which enable cells to function. Due to their importance in homeostasis, alterations …

Mutations in LRRK2 are associated with inherited Parkinson's disease (PD) in a large
number of families, and the genetic locus containing the LRRK2 gene contains a risk factor …

Abstract The International Molecular Exchange (IMEx) Consortium provides scientists with a
single body of experimentally verified protein interactions curated in rich contextual detail to …

Mutations in the Leucine Rich Repeat Kinase 2 (LRRK2) gene are linked to autosomal
dominant Parkinson's disease (PD), and genetic variations at the LRRK2 locus are …

LRRK2 (Leucine-Rich Repeat Kinase 2) is a gene whose specific mutations cause
Parkinson's disease (PD), the most common neurodegenerative movement disorder. LRRK2 …

Signal transduction cascades governed by kinases and GTPases are a critical component of
the command and control of cellular processes, with the precise outcome partly determined …

Parkinson's disease is a common neurodegenerative disorder and is clinically characterized
by bradykinesia, rigidity, and resting tremor. Missense mutations in the leucine‐rich repeat …

Mutations in LRRK2 are the most common genetic cause of Parkinson's disease. Despite
substantial research efforts, the physiological and pathological role of this multidomain …

Parkinson's disease is a neurodegenerative condition initially characterized by the presence
of tremor, muscle stiffness and impaired balance, with the deposition of insoluble protein …