Virtually all adults with Down syndrome (DS) show the neuropathological changes of
Alzheimer disease (AD) by the age of 40 years. This association is partially due to …

Many aspects of cognition and behaviour are regulated by noradrenergic projections to the
forebrain originating from the locus coeruleus, acting through alpha and beta …

Brain‐derived neurotrophic factor (BDNF) is a neurotrophin that is vital to the survival,
growth, and maintenance of neurons in key brain circuits involved in emotional and …

The number of the elderly across the globe will approximate 2.1 billion by 2050. Juxtaposed
against this burgeoning segment of the population is evidence that nonpathological aging is …

A major feature of Alzheimer's disease (AD) is the loss of noradrenergic locus coeruleus
(LC) projection neurons that mediate attention, memory, and arousal. However, the extent to …

Alzheimer's disease (AD) is neuropathologically characterized by the intracellular
accumulation of hyperphosphorylated tau and the extracellular deposition of amyloid-β …

Background Successful development of agents that improve cognition and behavior in
Alzheimer's disease (AD) is critical to improving the lives of patients manifesting the …

The locus coeruleus (LC), a major origin of noradrenergic projections in the central nervous
system (CNS), may serve a critical role in the pathogenesis of neurodegenerative disorders …

Background Dysfunction of the locus coeruleus-noradrenergic system occurs early in
Alzheimer's disease, contributing to cognitive and neuropsychiatric symptoms in some …

Aside from its roles in as a classical neurotransmitter involved in regulation of behavior,
noradrenaline (NA) has other functions in the CNS. This includes restricting the …