15-Lipoxygenase inhibitors: a patent review
H Sadeghian, A Jabbari - Expert opinion on therapeutic patents, 2016 - Taylor & Francis
Introduction: 15-Lipoxygenases (15-LOXes) are a family of iron-containing proteins that
have the capability for unsaturated fatty acid peroxidation in animals and plants. Two types …
have the capability for unsaturated fatty acid peroxidation in animals and plants. Two types …
Discovery of potent and selective inhibitors of human reticulocyte 15-lipoxygenase-1
There are a variety of lipoxygenases in the human body (hLO), each having a distinct role in
cellular biology. Human reticulocyte 15-lipoxygenase-1 (15-hLO-1), which catalyzes the …
cellular biology. Human reticulocyte 15-lipoxygenase-1 (15-hLO-1), which catalyzes the …
Synthesis and SAR studies of mono O-prenylated coumarins as potent 15-lipoxygenase inhibitors
All of the mono isopentenyloxy,-geranyloxy and-farnesyloxy derivatives of coumarin were
synthesized and their inhibitory potency against soybean 15-lipoxygenase (SLO) and …
synthesized and their inhibitory potency against soybean 15-lipoxygenase (SLO) and …
α-Glucosidase inhibition, 15-lipoxygenase inhibition, and brine shrimp toxicity of extracts and isolated compounds from Terminalia macroptera leaves
AT Pham, KE Malterud, BS Paulsen, D Diallo… - Pharmaceutical …, 2014 - Taylor & Francis
Abstract Context: Terminalia macroptera Guill. & Perr.(Combretaceae), a tree that grows in
West Africa, has been used in traditional medicine against a variety of diseases such as …
West Africa, has been used in traditional medicine against a variety of diseases such as …
Phenylpropionamides, Piperidine, and Phenolic Derivatives from the Fruit of Ailanthus altissima
JC Ni, JT Shi, QW Tan, QJ Chen - Molecules, 2017 - mdpi.com
Four novel compounds—two phenylpropionamides, one piperidine, and one phenolic
derivatives—were isolated and identified from the fruit of a medicinal plant, Ailanthus …
derivatives—were isolated and identified from the fruit of a medicinal plant, Ailanthus …
Synthesis and SAR study of 4, 5-diaryl-1H-imidazole-2 (3H)-thione derivatives, as potent 15-lipoxygenase inhibitors
A Assadieskandar, M Amini, M Salehi… - Bioorganic & medicinal …, 2012 - Elsevier
A series of 4, 5-diaryl-1H-imidazole-2 (3H)-thione was synthesized and their inhibitory
potency against soybean 15-lipoxygenase and free radical scavenging activities were …
potency against soybean 15-lipoxygenase and free radical scavenging activities were …
Pyrazole-based sulfonamide and sulfamides as potent inhibitors of mammalian 15-lipoxygenase
K Ngu, DS Weinstein, W Liu, C Langevine… - Bioorganic & medicinal …, 2011 - Elsevier
A series of inhibitors of mammalian 15-lipoxygenase (15-LO) based on a 3, 4, 5-tri-
substituted pyrazole scaffold is described. Replacement of a sulfonamide functionality in the …
substituted pyrazole scaffold is described. Replacement of a sulfonamide functionality in the …
Pd-catalyzed decarboxylative cross-couplings of potassium malonate monoesters with aryl halides
YS Feng, W Wu, ZQ Xu, Y Li, M Li, HJ Xu - Tetrahedron, 2012 - Elsevier
An efficient catalytic protocol for Pd-catalyzed decarboxylative cross-coupling of potassium
malonate monoesters and derivatives with aryl bromides and chlorides are described …
malonate monoesters and derivatives with aryl bromides and chlorides are described …
Enzymatic hybridization of α-lipoic acid with bioactive compounds in ionic solvents
AA Papadopoulou, MH Katsoura… - Bioresource …, 2013 - Elsevier
The lipase-catalyzed molecular hybridization of α-lipoic acid (LA) with bioactive compounds
pyridoxine, tyrosol and tyramine was performed in ionic solvents and deep eutectic solvents …
pyridoxine, tyrosol and tyramine was performed in ionic solvents and deep eutectic solvents …
In Vitro Anti-Diabetic, Anti-Inflammatory, Antioxidant Activities and Toxicological Study of Optimized Psychotria malayana Jack Leaves Extract
Psychotria malayana Jack (Family: Rubiaceae, local name: Salung) is a traditional herb
used to treat diabetes. A previous study by our research group demonstrated that P …
used to treat diabetes. A previous study by our research group demonstrated that P …