Infections, inflammation and epilepsy

A Vezzani, RS Fu**ami, HS White, PM Preux… - Acta …, 2016 - Springer
Epilepsy is the tendency to have unprovoked epileptic seizures. Anything causing structural
or functional derangement of brain physiology may lead to seizures, and different conditions …

The impact of microglial activation on blood-brain barrier in brain diseases

ACC da Fonseca, D Matias, C Garcia… - Frontiers in cellular …, 2014 - frontiersin.org
The blood-brain barrier (BBB), constituted by an extensive network of endothelial cells (ECs)
together with neurons and glial cells, including microglia, forms the neurovascular unit …

Animal models of epilepsy: use and limitations

L Kandratavicius, PA Balista… - Neuropsychiatric …, 2014 - Taylor & Francis
Epilepsy is a chronic neurological condition characterized by recurrent seizures that affects
millions of people worldwide. Comprehension of the complex mechanisms underlying …

Glia and epilepsy: excitability and inflammation

O Devinsky, A Vezzani, S Najjar, NC De Lanerolle… - Trends in …, 2013 - cell.com
Epilepsy is characterized by recurrent spontaneous seizures due to hyperexcitability and
hypersynchrony of brain neurons. Current theories of pathophysiology stress neuronal …

The role of inflammation in epilepsy

A Vezzani, J French, T Bartfai, TZ Baram - Nature reviews neurology, 2011 - nature.com
Epilepsy is the third most common chronic brain disorder, and is characterized by an
enduring predisposition to generate seizures. Despite progress in pharmacological and …

The kainic acid models of temporal lobe epilepsy

E Rusina, C Bernard, A Williamson - Eneuro, 2021 - eneuro.org
Experimental models of epilepsy are useful to identify potential mechanisms of
epileptogenesis, seizure genesis, comorbidities, and treatment efficacy. The kainic acid (KA) …

Cytokines in new‐onset refractory status epilepticus predict outcomes

A Hanin, J Cespedes, K Dorgham, Y Pulluru… - Annals of …, 2023 - Wiley Online Library
Objective The objective of this study was to investigate inflammation using cerebrospinal
fluid (CSF) and serum cytokines/chemokines in patients with new‐onset refractory status …

Inflammation in epileptogenesis after traumatic brain injury

KM Webster, M Sun, P Crack, TJ O'Brien… - Journal of …, 2017 - Springer
Background Epilepsy is a common and debilitating consequence of traumatic brain injury
(TBI). Seizures contribute to progressive neurodegeneration and poor functional and …

Autoimmune seizures and epilepsy

C Geis, J Planagumà, M Carreño… - The Journal of …, 2019 - Am Soc Clin Investig
The rapid expansion in the number of encephalitis disorders associated with autoantibodies
against neuronal proteins has led to an incremental increase in use of the term “autoimmune …

Inflammation and reactive oxygen species as disease modifiers in epilepsy

G Terrone, S Balosso, A Pauletti, T Ravizza… - …, 2020 - Elsevier
Neuroinflammation and reactive oxygen and nitrogen species are rapidly induced in the
brain after acute cerebral injuries that are associated with an enhanced risk for epilepsy in …