Traditional therapeutic approaches such as chemotherapy and radiation therapy have
burdened cancer patients with onerous physical and psychological challenges …

CRISPR screens are a powerful source of biological discovery, enabling the unbiased
interrogation of gene function in a wide range of applications and species. In pooled …

Tumours employ various tactics to adapt and eventually resist immune attack. These
mechanisms are collectively called adaptive immune resistance (AIR). The first defined and …

Glioblastoma (GBM), the predominant and primary malignant intracranial tumor, poses a
formidable challenge due to its immunosuppressive microenvironment, thereby confounding …

Glycosylation is the most abundant and diverse form of post-translational modification of
proteins that is common to all eukaryotic cells. Enzymatic glycosylation of proteins involves a …

Chimeric antigen receptor (CAR)-T cell-based immunotherapy for cancer and
immunological diseases has made great strides, but it still faces multiple hurdles. Finding …

Conspectus Cancer therapy is routinely performed in the clinic to cure cancer and control its
progression, wherein therapeutic agents are generally used. To reduce side effects …

Improving effector activity of antigen-specific T cells is a major goal in cancer
immunotherapy. Despite the identification of several effector T cell (T EFF)-driving …

Strategies of improving vaccine targeting ability toward lymph nodes have been attracting
considerable interest in recent years, though there are remaining delivery barriers based on …

Somatic mutations in nonmalignant tissues accumulate with age and injury, but whether
these mutations are adaptive on the cellular or organismal levels is unclear. To interrogate …