Linking lichen metabolites to genes: Emerging concepts and lessons from molecular biology and metagenomics

G Singh - Journal of Fungi, 2023 - mdpi.com
Lichen secondary metabolites have tremendous pharmaceutical and industrial potential.
Although more than 1000 metabolites have been reported from lichens, less than 10 have …

Breaking into nature's secret medicine cabinet: lichens–a biochemical goldmine ready for discovery

G Singh, F Dal Grande, FM Martin… - New …, 2025 - Wiley Online Library
Secondary metabolites are a crucial source of bioactive compounds playing a key role in the
development of new pharmaceuticals. Recently, biosynthetic research has benefited …

Metagenomics Shines Light on the Evolution of “Sunscreen” Pigment Metabolism in the Teloschistales (Lichen-Forming Ascomycota)

T Llewellyn, RW Nowell, A Aptroot… - Genome biology and …, 2023 - academic.oup.com
Fungi produce a vast number of secondary metabolites that shape their interactions with
other organisms and the environment. Characterizing the genes underpinning metabolite …

Discovery and excavation of lichen bioactive natural products

M Ren, S Jiang, Y Wang, X Pan, F Pan… - Frontiers in …, 2023 - frontiersin.org
Lichen natural products are a tremendous source of new bioactive chemical entities for drug
discovery. The ability to survive in harsh conditions can be directly correlated with the …

Mechanism behind the programmed biosynthesis of heterotrimeric fungal depside thielavin A

Q Ji, H **ang, WG Wang, Y Matsuda - Angewandte Chemie, 2024 - Wiley Online Library
Thielavin A (1) is a fungal depside composed of one 3‐methylorsellinic acid and two 3, 5‐
dimethylorsellinic acid units. It displays diverse biological activities. However, the …

[HTML][HTML] High Diversity of Type I Polyketide Genes in Bacidia rubella as Revealed by the Comparative Analysis of 23 Lichen Genomes

JV Gerasimova, A Beck, S Werth, P Resl - Journal of Fungi, 2022 - mdpi.com
Fungi involved in lichen symbioses produce a large array of secondary metabolites that are
often diagnostic in the taxonomic delimitation of lichens. The most common lichen …

Biosynthetic Potential of Hypogymnia Holobionts: Insights into Secondary Metabolite Pathways

N Ahmad, M Ritz, A Calchera, J Otte, I Schmitt… - Journal of Fungi, 2023 - mdpi.com
Lichens are symbiotic associations consisting of a photobiont (algae or cyanobacteria) and
a mycobiont (fungus). They are known to produce a variety of unique secondary metabolites …

Geministatins: new depside antibiotics from the fungus Austroacremonium gemini

A Crombie, JA Kalaitzis, R Chen, D Vuong… - The Journal of …, 2024 - nature.com
Two new depside antibiotics, geministatins A (1) and B (2), were isolated from the fungus
Austroacremonium gemini MST-FP2131 (Sordariomycetes, Ascomycota), which was …

Tridepsides as potential bioactives: A review on their chemistry and the global distribution of their lichenic and non-lichenic natural sources

H Norouzi, M Sohrabi, M Yousefi… - Frontiers in Fungal …, 2023 - frontiersin.org
Tridepsides, as fully oxidized polyketides, have been known to exist in lichens for more than
a century. Recent studies have showed that these possible defensive lichenochemicals …

Genome mining as a biotechnological tool for the discovery of novel biosynthetic genes in lichens

G Singh, F Dal Grande, I Schmitt - Frontiers in Fungal Biology, 2022 - frontiersin.org
Natural products (NPs) and their derivatives are a major contributor to modern medicine.
Historically, microorganisms such as bacteria and fungi have been instrumental in …