The observation that heart failure with reduced ejection fraction is associated with elevated
circulating levels of pro-inflammatory cytokines opened a new area of research that has …

Recognizing the importance of leukocyte trafficking in inflammation led to some therapeutic
breakthroughs. However, many inflammatory pathologies remain without specific therapy …

Background: Inflammation resolution and cardiac repair initiation after myocardial infarction
(MI) require timely activation of reparative signals. Histone lactylation confers macrophage …

The immune system plays a pivotal role in the initiation, development and resolution of
inflammation following insult or damage to organs. The heart is a vital organ which supplies …

Novel experimental approaches such as fate-map** and single-cell analysis have brought
fresh insight into monocyte development and function over the past decade and helped …

The burden of heart failure (HF), develo** after myocardial infarction MI, still represents a
major issue in clinical practice. Failure of appropriate resolution of inflammation during post …

Understanding tissue macrophage biology has become challenging in recent years due the
ever-increasing complexity in macrophage-subset identification and functional …

Improvements in early interventions after acute myocardial infarction (AMI), notably, the
increased use of timely reperfusion therapy, have increased survival dramatically in recent …

The past few decades have generated growing recognition that the immune system makes
an important contribution to cardiac development, composition and function. Immune cells …

Besides cardiomyocytes (CM), the heart contains numerous interstitial cell types which play
key roles in heart repair, regeneration and disease, including fibroblast, vascular and …