Endocytosis is a key cellular pathway required for the internalization of cellular nutrients,
lipids and receptor-bound cargoes. It is also critical for the recycling of cellular components …

Alzheimer's disease (AD) is a progressive neurodegenerative disease with phenotypic
changes closely associated with both genetic variants and imaging pathology. Brain …

BIN1, a member of the BAR adaptor protein family, is a significant late-onset Alzheimer
disease risk factor. Here, we investigate BIN1 function in the brain using conditional …

Genetic studies in late-onset Alzheimer disease (LOAD) are aimed at identifying core
disease mechanisms and providing potential biomarkers and drug candidates to improve …

Intelligence is a socially and scientifically interesting topic because of its prominence in
human behavior, yet there is little clarity on how the neuroimaging and neurobiological …

Alzheimer's disease is the most common neurodegenerative disease, and has a high level
of genetic heritability and population heterogeneity. In this study, we performed the whole …

The cerebral ventricles are recognized as windows into brain development and disease, yet
their genetic architectures, underlying neural mechanisms and utility in maintaining brain …

Genome-wide association studies identified the BIN1 locus as a leading modulator of
genetic risk in Alzheimer's disease (AD). One limitation in understanding BIN1's contribution …

Alzheimer's dementia commonly impacts the health of older adults and lacks any
preventative therapy. While Alzheimer's dementia risk has a substantial genetic component …

The Clusterin (CLU) gene, also known as apolipoprotein J (ApoJ), is currently the third most
associated late-onset Alzheimer's disease (LOAD) risk gene. However, little was known …