Short-chain fatty acids (SCFAs), the end products of fermentation of dietary fibers by the
anaerobic intestinal microbiota, have been shown to exert multiple beneficial effects on …

Lipid metabolism, in particular the synthesis of fatty acids (FAs), is an essential cellular
process that converts nutrients into metabolic intermediates for membrane biosynthesis …

Metformin is a widely used drug for treatment of type 2 diabetes with no defined cellular
mechanism of action. Its glucose-lowering effect results from decreased hepatic glucose …

adenosine monophosphate (AMP)-activated protein kinase (AMPK) is an evolutionarily
conserved serine/threonine kinase that was originally identified as the key player in …

Since the discovery of AMP-activated protein kinase (AMPK) as a central regulator of energy
homeostasis, many exciting insights into its structure, regulation and physiological roles …

The function and survival of all organisms is dependent on the dynamic control of energy
metabolism, when energy demand is matched to energy supply. The AMP-activated protein …

Noncommunicable diseases are chronic diseases that contribute to death worldwide, but
these diseases can be prevented and mitigated with regular exercise. Exercise activates …

An increased rate of lipid synthesis in cancerous tissues has long been recognised as an
important aspect of the rewired metabolism of transformed cells. However, the contribution of …

AMP-activated protein kinase (AMPK) is the downstream component of a kinase cascade
that plays a pivotal role in energy homeostasis. Activation of AMPK requires phosphorylation …

We have developed a sensitive assay for the AMP-activated protein kinase kinase, the
upstream component in the AMP-activated protein kinase cascade. Phosphorylation and …