Germinal centers
Germinal centers (GCs) were described more than 125 years ago as compartments within
secondary lymphoid organs that contained mitotic cells. Since then, it has become clear that …
secondary lymphoid organs that contained mitotic cells. Since then, it has become clear that …
Follicular helper T cells
Although T cell help for B cells was described several decades ago, it was the identification
of CXCR5 expression by B follicular helper T (Tfh) cells and the subsequent discovery of …
of CXCR5 expression by B follicular helper T (Tfh) cells and the subsequent discovery of …
[HTML][HTML] CXCL13-producing TFH cells link immune suppression and adaptive memory in human breast cancer
T follicular helper cells (T FH cells) are important regulators of antigen-specific B cell
responses. The B cell chemoattractant CXCL13 has recently been linked with T FH cell …
responses. The B cell chemoattractant CXCL13 has recently been linked with T FH cell …
Circulating precursor CCR7loPD-1hi CXCR5+ CD4+ T cells indicate Tfh cell activity and promote antibody responses upon antigen reexposure
Summary Follicular B helper T (Tfh) cells support high affinity and long-term antibody
responses. Here we found that within circulating CXCR5+ CD4+ T cells in humans and …
responses. Here we found that within circulating CXCR5+ CD4+ T cells in humans and …
Interleukin-2 inhibits germinal center formation by limiting T follicular helper cell differentiation
A Ballesteros-Tato, B León, BA Graf, A Moquin… - Immunity, 2012 - cell.com
T follicular helper (Tfh) cells promote T cell-dependent humoral immune responses by
providing T cell help to B cells and by promoting germinal center (GC) formation and long …
providing T cell help to B cells and by promoting germinal center (GC) formation and long …
T follicular helper cell dynamics in germinal centers
T follicular helper (TFH) cells are a specialized subset of effector T cells that provide help to
and thereby select high-affinity B cells in germinal centers (GCs). To examine the dynamic …
and thereby select high-affinity B cells in germinal centers (GCs). To examine the dynamic …
T follicular helper cells and T follicular regulatory cells in rheumatic diseases
As a hallmark of autoimmune rheumatic diseases, autoantibodies have been used in
diagnosis for decades. However, the immunological mechanism underlying their generation …
diagnosis for decades. However, the immunological mechanism underlying their generation …
Bcl6 and Maf cooperate to instruct human follicular helper CD4 T cell differentiation
Abstract Follicular helper CD4 T (Tfh) cells provide B cells with signals that are important for
the generation of high-affinity Abs and immunological memory and, therefore, are critical for …
the generation of high-affinity Abs and immunological memory and, therefore, are critical for …
The development and fate of follicular helper T cells defined by an IL-21 reporter mouse
Germinal centers require CD4+ follicular helper T cells (TFH cells), whose hallmark is
expression of the transcriptional repressor Bcl-6, the chemokine receptor CXCR5 and …
expression of the transcriptional repressor Bcl-6, the chemokine receptor CXCR5 and …
Early Th1 cell differentiation is marked by a Tfh cell-like transition
S Nakayamada, Y Kanno, H Takahashi, D Jankovic… - Immunity, 2011 - cell.com
Follicular helper T (Tfh) cells comprise an important subset of helper T cells; however, their
relationship with other helper lineages is incompletely understood. Herein, we showed …
relationship with other helper lineages is incompletely understood. Herein, we showed …