Engineering siRNA therapeutics: challenges and strategies

SS Ali Zaidi, F Fatima, SA Ali Zaidi, D Zhou… - Journal of …, 2023 - Springer
Small interfering RNA (siRNA) is a potential method of gene silencing to target specific
genes. Although the US Food and Drug Administration (FDA) has approved multiple siRNA …

Biopolymers based aerogels: A review on revolutionary solutions for smart therapeutics delivery

HPSA Khalil, EB Yahya, F Jummaat, AS Adnan… - Progress in Materials …, 2023 - Elsevier
Biopolymers-based aerogels have gained the attention of many scientists in medical and
pharmaceutical applications. Biopolymers-based aerogels are utilized extensively in the …

Oligonucleotide therapy: An emerging focus area for drug delivery in chronic inflammatory respiratory diseases

M Mehta, D Tewari, G Gupta, R Awasthi, H Singh… - Chemico-biological …, 2019 - Elsevier
Oligonucleotide-based therapies are advanced novel interventions used in the management
of various respiratory diseases such as asthma and Chronic Obstructive Pulmonary Disease …

Strategies, design, and chemistry in siRNA delivery systems

Y Dong, DJ Siegwart, DG Anderson - Advanced drug delivery reviews, 2019 - Elsevier
Emerging therapeutics that utilize RNA interference (RNAi) have the potential to treat broad
classes of diseases due to their ability to reversibly silence target genes. In August 2018, the …

Advances in biomaterials for drug delivery

OS Fenton, KN Olafson, PS Pillai… - Advanced …, 2018 - Wiley Online Library
Advances in biomaterials for drug delivery are enabling significant progress in biology and
medicine. Multidisciplinary collaborations between physical scientists, engineers, biologists …

Review of polysaccharide particle-based functional drug delivery

TG Barclay, CM Day, N Petrovsky, S Garg - Carbohydrate polymers, 2019 - Elsevier
This review investigates the significant role polysaccharide particles play in functional drug
delivery. The importance of these systems is due to the wide variety of polysaccharides and …

Chitosan as biomaterial in drug delivery and tissue engineering

SM Ahsan, M Thomas, KK Reddy… - International journal of …, 2018 - Elsevier
Chitin is one of the most abundant polysaccharide found on earth. The deacetylated form of
chitin viz. chitosan has been reported for its various important pharmacological properties …

Advances in the delivery of RNA therapeutics: from concept to clinical reality

JC Kaczmarek, PS Kowalski, DG Anderson - Genome medicine, 2017 - Springer
The rapid expansion of the available genomic data continues to greatly impact biomedical
science and medicine. Fulfilling the clinical potential of genetic discoveries requires the …

The potential of siRNA based drug delivery in respiratory disorders: Recent advances and progress

K Dua, R Wadhwa, G Singhvi, V Rapalli… - Drug development …, 2019 - Wiley Online Library
Lung diseases are the leading cause of mortality worldwide. The currently available
therapies are not sufficient, leading to the urgent need for new therapies with sustained anti …

Nanoparticle‐mediated double‐stranded RNA delivery system: a promising approach for sustainable pest management

S Yan, BY Ren, J Shen - Insect Science, 2021 - Wiley Online Library
RNA interference (RNAi) targeting lethal genes in insects has great potential for sustainable
crop protection. Compared with traditional double‐stranded (ds) RNA delivery systems …