Intra-plastid proteases play crucial and diverse roles in the development and maintenance
of non-photosynthetic plastids and chloroplasts. Formation and maintenance of a functional …

Elimination of non-functional or unwanted proteins is critical for cell growth and regulation. In
bacteria, ATP-dependent proteases target cytoplasmic proteins for degradation, contributing …

In the important human pathogen Staphylococcus aureus the cytoplasmic ClpP protease is
essential for mounting cellular stress responses and for virulence. To directly identify …

Regulated proteolysis by ATP-dependent proteases is universal in all living cells. Bacterial
ClpC, a member of the Clp/Hsp100 family of AAA+ proteins (ATPases associated with …

A repertoire of proteolysis-targeting signals known as degrons is a necessary component of
protein homeostasis in every living cell. In bacteria, degrons can be used in place of …

Highlights•Regulated protein degradation in bacteria relies on intrinsic protease specificity
and adaptor-mediated elaboration of protease specificity.•Adaptors acting as simple …

Ring-forming AAA+ chaperones exert ATP-fueled substrate unfolding by threading through a
central pore. This activity is potentially harmful requiring mechanisms for tight repression …

ABSTRACT S. aureus combats cell wall antibiotic stress by altered gene expression
mediated by various environmental signal sensors. In this study, we examined the …

HitRS is a two-component system that responds to cell envelope damage in the human
pathogen Bacillus anthracis. Here we identify an RNA-binding protein, KrrA, that regulates …

ABSTRACT In Streptococcus thermophilus, the ComRS regulatory system governs the
transcriptional level of comX expression and, hence, controls the early stage of competence …