Aldehyde dehydrogenase (ALDH) is a superfamily of enzymes that detoxify a variety of
endogenous and exogenous aldehydes and are required for the biosynthesis of retinoic …

The lineage transition between epithelium and mesenchyme is a process known as
epithelial–mesenchymal transition (EMT), by which polarized epithelial cells lose their …

Aldehyde dehydrogenases (ALDHs) belong to a superfamily of enzymes that play a key role
in the metabolism of aldehydes of both endogenous and exogenous derivation. The human …

Application of stem cell biology to breast cancer research has been limited by the lack of
simple methods for identification and isolation of normal and malignant stem cells. Utilizing …

Purpose: To examine the role of cancer stem cells (CSC) in mediating metastasis in
inflammatory breast cancer (IBC) and the association of these cells with patient outcome in …

Normal stem cells and cancer stem cells (CSCs) share similar properties, in that both have
the capacity to self-renew and differentiate into multiple cell types. In both the normal stem …

Tumor contains small population of cancer stem cells (CSC) that are responsible for its
maintenance and relapse. Analysis of these CSCs may lead to effective prognostic and …

Critical limb ischemia (CLI), the most severe form of peripheral artery disease, is
characterized by pain at rest and non-healing ulcers in the lower extremities. For patients …

Haematopoietic stem cells (HSCs) regenerate blood cells throughout the lifespan of an
organism. With age, the functional quality of HSCs declines, partly owing to the …

Background In accord with the cancer stem cell (CSC) theory, only a small subset of cancer
cells are capable of forming tumors. We previously reported that CD44 isolates tumorigenic …