The induced pluripotent stem cell (iPSC) technology has transformed in vitro research and
holds great promise to advance regenerative medicine. iPSCs have the capacity for an …

Eukaryotic genomes store information on many levels, including their linear DNA sequence,
the posttranslational modifications of its constituents (epigenetic modifications), and its three …

Single-molecule localization microscopy (SMLM) is a powerful tool for observing structures
beyond the diffraction limit of light. Combining SMLM with engineered point spread functions …

The genome is traditionally divided into condensed heterochromatin and open euchromatin.
However, recent findings challenge this binary classification and the notion that chromatin …

Visualizing and measuring molecular-scale interactions in living cells represents a major
challenge, but recent advances in single-molecule super-resolution microscopy are bringing …

Live cell assays provide real-time data of cellular responses. In combination with
microfluidics, applications such as automated and high-throughput drug screening on live …

Chromatin remodeling, carried out by four major subfamilies of ATP-dependent remodeler
complexes across eukaryotes, alleviates the topological challenge posed by nucleosomes …

The human genome consists of 23 chromosome pairs (22 autosomes and one pair of sex
chromosomes), with 46 chromosomes in a normal cell. In the interphase nucleus, the 2 m …

As cells exit the pluripotent state and begin to commit to a specific lineage they must activate
genes appropriate for that lineage while silencing genes associated with pluripotency and …

The ability of stem cells to divide and self-renew depends on a complex choreography of
molecular events that maintain the transcriptional oscillation of pluripotency genes. Only a …