Structural biology of complement receptors
J Santos-López, K de la Paz, FJ Fernández… - Frontiers in …, 2023 - frontiersin.org
The complement system plays crucial roles in a wide breadth of immune and inflammatory
processes and is frequently cited as an etiological or aggravating factor in many human …
processes and is frequently cited as an etiological or aggravating factor in many human …
Mechanism of activation and biased signaling in complement receptor C5aR1
The complement system plays an important role in the innate immune response to invading
pathogens. The complement fragment C5a is one of its important effector components and …
pathogens. The complement fragment C5a is one of its important effector components and …
Transcriptional reprogramming during human osteoclast differentiation identifies regulators of osteoclast activity
Enhanced osteoclastogenesis and osteoclast activity contribute to the development of
osteoporosis, which is characterized by increased bone resorption and inadequate bone …
osteoporosis, which is characterized by increased bone resorption and inadequate bone …
Functional profiling of the G protein-coupled receptor C3aR1 reveals ligand-mediated biased agonism
P Rodriguez, LJ Laskowski, JP Pallais, HA Bock… - Journal of Biological …, 2024 - jbc.org
G protein-coupled receptors (GPCRs) are leading druggable targets for several medicines,
but many GPCRs are still untapped for their therapeutic potential due to poor understanding …
but many GPCRs are still untapped for their therapeutic potential due to poor understanding …
Chemical synthesis of grafted cyclotides using a “plug and play” approach
Cyclotides are a diverse class of plant-derived cyclic, disulfide-rich peptides with a unique
cyclic cystine knot topology. Their remarkable structural stability and resistance to proteolytic …
cyclic cystine knot topology. Their remarkable structural stability and resistance to proteolytic …
Exploration of compounds to inhibit the Panton-Valentine leukocidin of Staphylococcus aureus
T Grebe, MT Sarkari, A Cherkaoui… - Medical Microbiology and …, 2024 - Springer
Abstract The Panton-Valentine leukocidin (PVL) of Staphylococcus aureus is associated
with necrotizing infections. After binding to complement 5a receptor (C5aR/CD88) and CD45 …
with necrotizing infections. After binding to complement 5a receptor (C5aR/CD88) and CD45 …
[HTML][HTML] Protocol for cell-based screening assay to measure ERK1/2 phosphorylation as a readout for complement receptor activation
The complement receptors C3aR and C5aR1 are promising therapeutic targets. Here, we
present a protocol to screen the effects of different agonists and antagonists on these …
present a protocol to screen the effects of different agonists and antagonists on these …
Complement peptide receptors in GtoPdb v. 2023.1
Complement peptide receptors (nomenclature as agreed by the NC-IUPHAR subcommittee
on Complement peptide receptors [113]) are activated by the endogenous~ 75 amino-acid …
on Complement peptide receptors [113]) are activated by the endogenous~ 75 amino-acid …
Structural insights into ligand-recognition, activation, and signaling-bias at the complement C5a receptor, C5aR1
Activation of the complement cascade is a critical part of our innate immune response
against invading pathogens, and it operates in a concerted fashion with the antibodies and …
against invading pathogens, and it operates in a concerted fashion with the antibodies and …
Transcriptional reprogramming during human osteoclast differentiation identifies regulators of osteoclast activity
Enhanced osteoclastogenesis and osteoclast activity contribute to the development of
osteoporosis, which is characterized by increased bone resorption and inadequate bone …
osteoporosis, which is characterized by increased bone resorption and inadequate bone …