Animal models of major depression: drawbacks and challenges
Major depression is a leading contributor to the global burden of disease. This situation is
mainly related to the chronicity and/or recurrence of the disorder, and to poor response to …
mainly related to the chronicity and/or recurrence of the disorder, and to poor response to …
[HTML][HTML] The chronic mild stress (CMS) model of depression: History, evaluation and usage
P Willner - Neurobiology of stress, 2017 - Elsevier
Now 30 years old, the chronic mild stress (CMS) model of depression has been used in>
1300 published studies, with a year-on-year increase rising to> 200 papers in 2015. Data …
1300 published studies, with a year-on-year increase rising to> 200 papers in 2015. Data …
Microglial NLRP3 inflammasome activation mediates IL-1β-related inflammation in prefrontal cortex of depressive rats
Y Pan, XY Chen, QY Zhang, LD Kong - Brain, behavior, and immunity, 2014 - Elsevier
Depression is an inflammatory disorder. Pro-inflammatory cytokine interleukin-1 beta (IL-1β)
may play a pivotal role in the central nervous system (CNS) inflammation of depression …
may play a pivotal role in the central nervous system (CNS) inflammation of depression …
Neurobiology of chronic mild stress: parallels to major depression
The chronic mild (or unpredictable/variable) stress (CMS) model was developed as an
animal model of depression more than 20 years ago. The foundation of this model was that …
animal model of depression more than 20 years ago. The foundation of this model was that …
[HTML][HTML] Animal models as tools to study the pathophysiology of depression
The incidence of depressive illness is high worldwide, and the inadequacy of currently
available drug treatments contributes to the significant health burden associated with …
available drug treatments contributes to the significant health burden associated with …
[HTML][HTML] Reliability of the chronic mild stress model of depression: A user survey
P Willner - Neurobiology of stress, 2017 - Elsevier
The chronic mild stress (CMS) model of depression is considered by many to be the animal
model of depression that has the greatest validity and translational potential, but it has often …
model of depression that has the greatest validity and translational potential, but it has often …
Neurogenetics of aggressive behavior: studies in rodents
Aggressive behavior is observed in many animal species, such as insects, fish, lizards,
frogs, and most mammals including humans. This wide range of conservation underscores …
frogs, and most mammals including humans. This wide range of conservation underscores …
Behavioural characterisation of chronic unpredictable stress based on ethologically relevant paradigms in rats
The chronic unpredictable stress (CUS) paradigm is extensively used in preclinical
research. However, CUS exhibits translational inconsistencies, some of them resulting from …
research. However, CUS exhibits translational inconsistencies, some of them resulting from …
Characterization of GABAergic marker expression in the chronic unpredictable stress model of depression
Background Evidence continues to build suggesting that the GABAergic neurotransmitter
system is altered in brains of patients with major depressive disorder. However, there is little …
system is altered in brains of patients with major depressive disorder. However, there is little …
Treatment-resistant depression: are animal models of depression fit for purpose?
P Willner, C Belzung - Psychopharmacology, 2015 - Springer
Background Resistance to antidepressant drug treatment remains a major health problem.
Animal models of depression are efficient in detecting effective treatments but have done …
Animal models of depression are efficient in detecting effective treatments but have done …