Simple Summary The authors report the most up-to-date review and a thorough meta-
analysis of inflammatory, immunological markers such as neutrophil-to-lymphocyte ratio …

Liquid biopsies collect and analyze tumor components in body fluids, and there is an
increasing interest in the investigation of liquid biopsies as a surrogate for tumor tissue in the …

Though surgical biopsies provide direct access to tissue for genomic characterization of
brain cancer, they are invasive and pose significant clinical risks. Brain cancer management …

Sonobiopsy is an emerging technology that combines focused ultrasound (FUS) with
microbubbles to enrich circulating brain disease-specific biomarkers for noninvasive …

Medulloblastoma (MB) is the most common malignant brain tumor in children. There
remains an unmet need for diagnostics to sensitively detect the disease, particularly …

Although blood-based liquid biopsy is a promising noninvasive technique to acquire a
comprehensive molecular tumor profile by detecting cancer-specific biomarkers (eg DNA …

Background Due to the blood-brain barrier, plasma is not an ideal source to evaluate the
genetic characteristics of central nervous system tumors. Thus, cerebrospinal fluid (CSF) is …

Glioblastoma (GBM) is the most common type of glioma and is uniformly fatal. Currently,
tumour heterogeneity and mutation acquisition are major impedances for tailoring …

Brain tumors include those that originate within the brain (primary tumors) as well as those
that arise from other cancers (metastatic tumors). The fragile nature of the brain poses a …

Circulating tumor DNA can be detected in the blood and body fluids of patients using
ultrasensitive technologies, which have the potential to improve cancer diagnosis, risk …