Cerebral oxygen extraction fraction MRI: Techniques and applications

D Jiang, H Lu - Magnetic resonance in medicine, 2022 - Wiley Online Library
The human brain constitutes 2% of the body's total mass but uses 20% of the oxygen. The
rate of the brain's oxygen utilization can be derived from a knowledge of cerebral blood flow …

[HTML][HTML] Multimodal comparisons of QSM and PET in neurodegeneration and aging

PM Cogswell, AP Fan - Neuroimage, 2023 - Elsevier
Quantitative susceptibility map** (QSM) has been used to study susceptibility changes
that may occur based on tissue composition and mineral deposition. Iron is a primary …

[HTML][HTML] Hemodynamic and metabolic correspondence of resting-state voxel-based physiological metrics in healthy adults

S Deng, CG Franklin, M O'Boyle, W Zhang, BL Heyl… - Neuroimage, 2022 - Elsevier
Voxel-based physiological (VBP) variables derived from blood oxygen level dependent
(BOLD) fMRI time-course variations include: amplitude of low frequency fluctuations (ALFF) …

[HTML][HTML] Evaluation of whole-brain oxygen metabolism in Alzheimer's disease using QSM and quantitative BOLD

A Yang, H Zhuang, L Du, B Liu, K Lv, J Luan, P Hu… - NeuroImage, 2023 - Elsevier
Objective The objective of this study was to evaluate the whole-brain pattern of oxygen
extraction fraction (OEF), cerebral blood flow (CBF), and cerebral metabolic rate of oxygen …

Spatiotemporal patterns of brain iron-oxygen metabolism in patients with Parkinson's disease

S Yan, J Lu, Y Li, J Cho, S Zhang, W Zhu, Y Wang - European Radiology, 2024 - Springer
Objectives Iron deposition and mitochondrial dysfunction are closely associated with the
genesis and progression of Parkinson's disease (PD). This study aims to extract …

Brain oxygen extraction fraction map** in patients with multiple sclerosis

J Cho, TD Nguyen, W Huang… - Journal of Cerebral …, 2022 - journals.sagepub.com
We aimed to demonstrate the feasibility of whole brain oxygen extraction fraction (OEF)
map** for measuring lesion specific and regional OEF abnormalities in multiple sclerosis …

Temporal clustering, tissue composition, and total variation for map** oxygen extraction fraction using QSM and quantitative BOLD

J Cho, P Spincemaille, TD Nguyen… - Magnetic resonance …, 2021 - Wiley Online Library
Purpose To improve the accuracy of quantitative susceptibility map** plus quantitative
blood oxygen level‐dependent magnitude (QSM+ qBOLD or QQ) based map** of oxygen …

Penumbra detection with oxygen extraction fraction using magnetic susceptibility in patients with acute ischemic stroke

Y Uchida, H Kan, H Inoue, M Oomura… - Frontiers in …, 2022 - frontiersin.org
Background The oxygen extraction fraction (OEF) has been applied to identify ischemic
penumbral tissue, but is difficult to use in an urgent care setting. This study aimed to …

QQ‐NET–using deep learning to solve quantitative susceptibility map** and quantitative blood oxygen level dependent magnitude (QSM+ qBOLD or QQ) based …

J Cho, J Zhang, P Spincemaille… - Magnetic resonance …, 2022 - Wiley Online Library
Purpose To improve accuracy and speed of quantitative susceptibility map** plus
quantitative blood oxygen level‐dependent magnitude (QSM+ qBOLD or QQ)‐based …

Clinical imaging of the penumbra in ischemic stroke: from the concept to the era of mechanical thrombectomy

L Chalet, T Boutelier, T Christen… - Frontiers in …, 2022 - frontiersin.org
The ischemic penumbra is defined as the severely hypoperfused, functionally impaired, at-
risk but not yet infarcted tissue that will be progressively recruited into the infarct core. Early …