An overview of active and passive targeting strategies to improve the nanocarriers efficiency to tumour sites

MF Attia, N Anton, J Wallyn, Z Omran… - Journal of Pharmacy …, 2019‏ - academic.oup.com
Objectives This review highlights both the physicochemical characteristics of the
nanocarriers (NCs) and the physiological features of tumour microenvironment (TME) to …

[HTML][HTML] Nanotechnology-based delivery of CRISPR/Cas9 for cancer treatment

X Xu, C Liu, Y Wang, O Koivisto, J Zhou, Y Shu… - Advanced drug delivery …, 2021‏ - Elsevier
Abstract CRISPR/Cas9 (Clustered Regularly Interspaced Short Palindromic Repeats-
associated protein 9) is a potent technology for gene-editing. Owing to its high specificity …

Peptide-based agents for cancer treatment: current applications and future directions

NTT Nhàn, T Yamada, KH Yamada - International Journal of Molecular …, 2023‏ - mdpi.com
Peptide-based strategies have received an enormous amount of attention because of their
specificity and applicability. Their specificity and tumor-targeting ability are applied to …

[HTML][HTML] Surface-modified lipid nanocarriers for crossing the blood-brain barrier (BBB): A current overview of active targeting in brain diseases

MI Teixeira, CM Lopes, MH Amaral, PC Costa - Colloids and Surfaces B …, 2023‏ - Elsevier
The blood-brain barrier (BBB) restricts the access of therapeutic agents to the brain,
complicating the treatment of neurological diseases, such as Alzheimer's disease (AD) …

[HTML][HTML] Alzheimer's disease: treatment strategies and their limitations

E Passeri, K Elkhoury, M Morsink, K Broersen… - International journal of …, 2022‏ - mdpi.com
Alzheimer's disease (AD) is the most frequent case of neurodegenerative disease and is
becoming a major public health problem all over the world. Many therapeutic strategies …

Ligand‐installed nanocarriers toward precision therapy

P Mi, H Cabral, K Kataoka - Advanced Materials, 2020‏ - Wiley Online Library
Abstract Development of drug‐delivery systems that selectively target neoplastic cells has
been a major goal of nanomedicine. One major strategy for achieving this milestone is to …

Peptide and protein nanoparticle conjugates: versatile platforms for biomedical applications

CD Spicer, C Jumeaux, B Gupta… - Chemical society …, 2018‏ - pubs.rsc.org
Peptide–and protein–nanoparticle conjugates have emerged as powerful tools for
biomedical applications, enabling the treatment, diagnosis, and prevention of disease. In …

Rethinking CRITID procedure of brain targeting drug delivery: circulation, blood brain barrier recognition, intracellular transport, diseased cell targeting, internalization …

S Ruan, Y Zhou, X Jiang, H Gao - Advanced science, 2021‏ - Wiley Online Library
The past decades have witnessed great progress in nanoparticle (NP)‐based brain‐
targeting drug delivery systems, while their therapeutic potentials are yet to be fully exploited …

[HTML][HTML] Progress and perspectives on targeting nanoparticles for brain drug delivery

H Gao - Acta Pharmaceutica Sinica B, 2016‏ - Elsevier
Due to the ability of the blood–brain barrier (BBB) to prevent the entry of drugs into the brain,
it is a challenge to treat central nervous system disorders pharmacologically. The …

Blood–Brain-Barrier-Penetrating Albumin Nanoparticles for Biomimetic Drug Delivery via Albumin-Binding Protein Pathways for Antiglioma Therapy

T Lin, P Zhao, Y Jiang, Y Tang, H **, Z Pan, H He… - ACS …, 2016‏ - ACS Publications
Nutrient transporters have been explored for biomimetic delivery targeting the brain. The
albumin-binding proteins (eg, SPARC and gp60) are overexpressed in many tumors for …