The OncoArray Consortium: a network for understanding the genetic architecture of common cancers

CI Amos, J Dennis, Z Wang, J Byun… - Cancer epidemiology …, 2017 - aacrjournals.org
Background: Common cancers develop through a multistep process often including
inherited susceptibility. Collaboration among multiple institutions, and funding from multiple …

Functional studies of lung cancer GWAS beyond association

E Long, H Patel, J Byun, CI Amos… - Human molecular …, 2022 - academic.oup.com
Fourteen years after the first genome-wide association study (GWAS) of lung cancer was
published, approximately 45 genomic loci have now been significantly associated with lung …

Cross-ancestry genome-wide meta-analysis of 61,047 cases and 947,237 controls identifies new susceptibility loci contributing to lung cancer

J Byun, Y Han, Y Li, J **a, E Long, J Choi, X **ao… - Nature …, 2022 - nature.com
To identify new susceptibility loci to lung cancer among diverse populations, we performed
cross-ancestry genome-wide association studies in European, East Asian and African …

Genomic analyses of flow-sorted Hodgkin Reed-Sternberg cells reveal complementary mechanisms of immune evasion

K Wienand, B Chapuy, C Stewart, AJ Dunford… - Blood …, 2019 - ashpublications.org
Classical Hodgkin lymphoma (cHL) is composed of rare malignant Hodgkin Reed-Sternberg
(HRS) cells within an extensive, but ineffective, inflammatory/immune cell infiltrate. HRS …

Three new pancreatic cancer susceptibility signals identified on chromosomes 1q32. 1, 5p15. 33 and 8q24. 21

M Zhang, Z Wang, O Obazee, J Jia, EJ Childs… - …, 2016 - pmc.ncbi.nlm.nih.gov
Genome-wide association studies (GWAS) have identified common pancreatic cancer
susceptibility variants at 13 chromosomal loci in individuals of European descent. To identify …

Assessing lung cancer absolute risk trajectory based on a polygenic risk model

RJ Hung, MT Warkentin, Y Brhane, N Chatterjee… - Cancer …, 2021 - aacrjournals.org
Lung cancer is the leading cause of cancer-related death globally. An improved risk
stratification strategy can increase efficiency of low-dose CT (LDCT) screening. Here we …

Fanconi anemia and dyskeratosis congenita/telomere biology disorders: two inherited bone marrow failure syndromes with genomic instability

MÓ Fiesco-Roa, B García-de Teresa… - Frontiers in …, 2022 - frontiersin.org
Inherited bone marrow failure syndromes (IBMFS) are a complex and heterogeneous group
of genetic diseases. To date, at least 13 IBMFS have been characterized. Their …

Common genetic variations in telomere length genes and lung cancer: a Mendelian randomisation study and its novel application in lung tumour transcriptome

RCC Penha, K Smith-Byrne, JR Atkins, PC Haycock… - elife, 2023 - elifesciences.org
Background: Genome-wide association studies (GWASs) have identified genetic
susceptibility variants for both leukocyte telomere length (LTL) and lung cancer …

Association between GWAS-identified lung adenocarcinoma susceptibility loci and EGFR mutations in never-smoking Asian women, and comparison with findings …

WJ Seow, K Matsuo, CA Hsiung… - Human molecular …, 2017 - academic.oup.com
To evaluate associations by EGFR mutation status for lung adenocarcinoma risk among
never-smoking Asian women, we conducted a meta-analysis of 11 loci previously identified …

Protein-altering germline mutations implicate novel genes related to lung cancer development

X Ji, S Mukherjee, MT Landi, Y Bosse, P Joubert… - Nature …, 2020 - nature.com
Few germline mutations are known to affect lung cancer risk. We performed analyses of rare
variants from 39,146 individuals of European ancestry and investigated gene expression …