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The OncoArray Consortium: a network for understanding the genetic architecture of common cancers
Background: Common cancers develop through a multistep process often including
inherited susceptibility. Collaboration among multiple institutions, and funding from multiple …
inherited susceptibility. Collaboration among multiple institutions, and funding from multiple …
Functional studies of lung cancer GWAS beyond association
Fourteen years after the first genome-wide association study (GWAS) of lung cancer was
published, approximately 45 genomic loci have now been significantly associated with lung …
published, approximately 45 genomic loci have now been significantly associated with lung …
Cross-ancestry genome-wide meta-analysis of 61,047 cases and 947,237 controls identifies new susceptibility loci contributing to lung cancer
To identify new susceptibility loci to lung cancer among diverse populations, we performed
cross-ancestry genome-wide association studies in European, East Asian and African …
cross-ancestry genome-wide association studies in European, East Asian and African …
Genomic analyses of flow-sorted Hodgkin Reed-Sternberg cells reveal complementary mechanisms of immune evasion
Classical Hodgkin lymphoma (cHL) is composed of rare malignant Hodgkin Reed-Sternberg
(HRS) cells within an extensive, but ineffective, inflammatory/immune cell infiltrate. HRS …
(HRS) cells within an extensive, but ineffective, inflammatory/immune cell infiltrate. HRS …
Three new pancreatic cancer susceptibility signals identified on chromosomes 1q32. 1, 5p15. 33 and 8q24. 21
Genome-wide association studies (GWAS) have identified common pancreatic cancer
susceptibility variants at 13 chromosomal loci in individuals of European descent. To identify …
susceptibility variants at 13 chromosomal loci in individuals of European descent. To identify …
Assessing lung cancer absolute risk trajectory based on a polygenic risk model
Lung cancer is the leading cause of cancer-related death globally. An improved risk
stratification strategy can increase efficiency of low-dose CT (LDCT) screening. Here we …
stratification strategy can increase efficiency of low-dose CT (LDCT) screening. Here we …
Fanconi anemia and dyskeratosis congenita/telomere biology disorders: two inherited bone marrow failure syndromes with genomic instability
MÓ Fiesco-Roa, B García-de Teresa… - Frontiers in …, 2022 - frontiersin.org
Inherited bone marrow failure syndromes (IBMFS) are a complex and heterogeneous group
of genetic diseases. To date, at least 13 IBMFS have been characterized. Their …
of genetic diseases. To date, at least 13 IBMFS have been characterized. Their …
Common genetic variations in telomere length genes and lung cancer: a Mendelian randomisation study and its novel application in lung tumour transcriptome
Background: Genome-wide association studies (GWASs) have identified genetic
susceptibility variants for both leukocyte telomere length (LTL) and lung cancer …
susceptibility variants for both leukocyte telomere length (LTL) and lung cancer …
Association between GWAS-identified lung adenocarcinoma susceptibility loci and EGFR mutations in never-smoking Asian women, and comparison with findings …
To evaluate associations by EGFR mutation status for lung adenocarcinoma risk among
never-smoking Asian women, we conducted a meta-analysis of 11 loci previously identified …
never-smoking Asian women, we conducted a meta-analysis of 11 loci previously identified …
Protein-altering germline mutations implicate novel genes related to lung cancer development
Few germline mutations are known to affect lung cancer risk. We performed analyses of rare
variants from 39,146 individuals of European ancestry and investigated gene expression …
variants from 39,146 individuals of European ancestry and investigated gene expression …