In order to fully understand any complex biochemical system from a mechanistic point of
view, it is necessary to have access to the three-dimensional structures of the molecular …

How cells move is a fundamental biological question. The directionality of adherent
migrating cells depends on the assembly and disassembly (turnover) of focal adhesions …

Septins are cytoskeletal proteins that assemble into hetero-oligomeric complexes and sense
micron-scale membrane curvature. During infection with Shigella flexneri, an invasive …

One of the major challenges of bottom-up synthetic biology is rebuilding a minimal cell
division machinery. From a reconstitution perspective, the animal cell division apparatus is …

The ability of cells to sense and communicate their shape is central to many of their
functions. Much is known about how cells generate complex shapes, yet how they sense …

Septins are involved in many important cellular processes, and septin dysfunction has been
implicated in various pathologies, such as cancer. Like other components of the …

Septins are cytoskeletal proteins conserved from algae and protists to mammals. A unique
feature of septins is their presence as heteromeric complexes that polymerize into filaments …

In order to form functional filaments, human septins must assemble into hetero-oligomeric
rod-like particles which polymerize end-to-end. The rules governing the assembly of these …

Uncontrolled cell proliferation leads to several pathologies, including cancer. Thus, this
process must be tightly regulated. The cell cycle accounts for cell proliferation, and its …

Septins are an example of subtle molecular recognition whereby different paralogues must
correctly assemble into functional filaments important for essential cellular events such as …