A molecular description of functional modules in the cell is the focus of many high-
throughput studies in the postgenomic era. A large portion of biomolecular interactions in …

The assembly of individual proteins into functional complexes is fundamental to nearly all
biological processes. In recent decades, many thousands of homomeric and heteromeric …

Is the order in which proteins assemble into complexes important for biological function?
Here, we seek to address this by searching for evidence of evolutionary selection for …

The present review focuses on the evolution of proteins and the impact of amino acid
mutations on function from a structural perspective. Proteins evolve under the law of natural …

INTRODUCTION The assembly of proteins into complexes is crucial for most biological
processes. The three-dimensional structures of many thousands of homomeric and …

G protein-coupled receptors (GPCRs) oligomerization has emerged as a vital characteristic
of receptor structure. Substantial experimental evidence supports the existence of GPCR …

Protein complex assembly often occurs while subunits are being translated, resulting in
complexes whose subunits were translated from the same mRNA in an allele-specific …

Many human genetic disorders are caused by mutations in protein‐coding regions of DNA.
Taking protein structure into account has therefore provided key insight into the molecular …

Ortholog protein complexes are responsible for equivalent functions in different organisms.
However, during evolution, each organism adapts to meet its physiological needs and the …

Many enzymes assemble into homomeric protein complexes comprising multiple copies of
one protein. Because structural form is usually assumed to follow function in biochemistry …