Individuals who maintain cognitive function despite high levels of Alzheimer's disease (AD)-
associated pathology are said to be 'resilient'to AD. Identifying mechanisms underlying …

With the rapid adoption of high-throughput omic approaches to analyze biological samples
such as genomics, transcriptomics, proteomics, and metabolomics, each analysis can …

Mouse models have been instrumental in understanding human disease biology and
proposing possible new treatments. The precise control of the environment and genetic …

The challenge of precision medicine is to model complex interactions among DNA variants,
phenotypes, development, environments, and treatments. We address this challenge by …

Insulin resistance is a cornerstone of obesity-related complications such as type 2 diabetes,
metabolic syndrome, and nonalcoholic fatty liver disease. A high rate of lipolysis is known to …

Bile acids (BAs) are complex and incompletely understood enterohepatic-derived hormones
that control whole-body metabolism. Here, we profiled postprandial BAs in the liver, feces …

Metabolic diseases are caused by a complex interplay between genetics and the
environment, yet many basic studies guiding our understanding of metabolism are confined …

Background & Aims Transporters of the SLC25 mitochondrial carrier superfamily bridge
cytoplasmic and mitochondrial metabolism by channeling metabolites across mitochondrial …

Ongoing studies in many species seek to understand the origins, architecture and
consequences of phenotypic variation under normal and dysfunctional conditions, with the …

Resilience of soils, ie, their ability to maintain functions or recover after disturbance, is
closely linked to the root-soil interface, the soil's power house. However, the limited …