Actinobacteria: current research and perspectives for bioremediation of pesticides and heavy metals
Actinobacteria exhibit cosmopolitan distribution since their members are widely distributed
in aquatic and terrestrial ecosystems. In the environment they play relevant ecological roles …
in aquatic and terrestrial ecosystems. In the environment they play relevant ecological roles …
Disease suppressive soils: new insights from the soil microbiome
Soils suppressive to soilborne pathogens have been identified worldwide for almost 60
years and attributed mainly to suppressive or antagonistic microorganisms. Rather than …
years and attributed mainly to suppressive or antagonistic microorganisms. Rather than …
Identification of thiotetronic acid antibiotic biosynthetic pathways by target-directed genome mining
Recent genome sequencing efforts have led to the rapid accumulation of uncharacterized or
“orphaned” secondary metabolic biosynthesis gene clusters (BGCs) in public databases …
“orphaned” secondary metabolic biosynthesis gene clusters (BGCs) in public databases …
Tetrameric c-di-GMP mediates effective transcription factor dimerization to control Streptomyces development
The cyclic dinucleotide c-di-GMP is a signaling molecule with diverse functions in cellular
physiology. Here, we report that c-di-GMP can assemble into a tetramer that mediates the …
physiology. Here, we report that c-di-GMP can assemble into a tetramer that mediates the …
Engineering of Streptomyces lividans for heterologous expression of secondary metabolite gene clusters
Y Ahmed, Y Rebets, MR Estévez, J Zapp… - Microbial cell …, 2020 - Springer
Background Heterologous expression of secondary metabolite gene clusters is used to
achieve increased production of desired compounds, activate cryptic gene clusters …
achieve increased production of desired compounds, activate cryptic gene clusters …
Cas12a-assisted precise targeted cloning using in vivo Cre-lox recombination
Direct cloning represents the most efficient strategy to access the vast number of
uncharacterized natural product biosynthetic gene clusters (BGCs) for the discovery of novel …
uncharacterized natural product biosynthetic gene clusters (BGCs) for the discovery of novel …
Streptomyces Endophytes Promote Host Health and Enhance Growth across Plant Species
SF Worsley, J Newitt, J Rassbach… - Applied and …, 2020 - Am Soc Microbiol
Streptomyces bacteria are ubiquitous in soils and are well known for producing secondary
metabolites, including antimicrobials. Increasingly, they are being isolated from plant roots …
metabolites, including antimicrobials. Increasingly, they are being isolated from plant roots …
Simultaneous bioremediation of Cr (VI) and lindane in soil by actinobacteria
Environments co-contaminated with metals and organic compounds are difficult to
remediate. Actinobacteria is an important group of microorganisms found in soils, with high …
remediate. Actinobacteria is an important group of microorganisms found in soils, with high …
Analysis of the prodiginine biosynthesis gene cluster of Streptomyces coelicolor A3 (2): new mechanisms for chain initiation and termination in modular multienzymes
Background: Prodiginines are a large family of pigmented oligopyrrole antibiotics with
medicinal potential as immunosuppressants and antitumour agents that are produced by …
medicinal potential as immunosuppressants and antitumour agents that are produced by …
Chemical perturbation of secondary metabolism demonstrates important links to primary metabolism
A Craney, C Ozimok, SM Pimentel-Elardo, A Capretta… - Chemistry & biology, 2012 - cell.com
Bacterially produced secondary metabolites are used as antibiotics, anticancer drugs, and
for many other medicinal applications. The mechanisms that limit the production of these …
for many other medicinal applications. The mechanisms that limit the production of these …