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Alternative polyadenylation of mRNA precursors
Alternative polyadenylation (APA) is an RNA-processing mechanism that generates distinct
3′ termini on mRNAs and other RNA polymerase II transcripts. It is widespread across all …
3′ termini on mRNAs and other RNA polymerase II transcripts. It is widespread across all …
Alternative cleavage and polyadenylation: extent, regulation and function
The 3′ end of most protein-coding genes and long non-coding RNAs is cleaved and
polyadenylated. Recent discoveries have revealed that a large proportion of these genes …
polyadenylated. Recent discoveries have revealed that a large proportion of these genes …
Dynamic analyses of alternative polyadenylation from RNA-seq reveal a 3′-UTR landscape across seven tumour types
Alternative polyadenylation (APA) is a pervasive mechanism in the regulation of most
human genes, and its implication in diseases including cancer is only beginning to be …
human genes, and its implication in diseases including cancer is only beginning to be …
Alternative mRNA transcription, processing, and translation: insights from RNA sequencing
The human transcriptome comprises> 80000 protein-coding transcripts and the estimated
number of proteins synthesized from these transcripts is in the range of 250000 to 1 million …
number of proteins synthesized from these transcripts is in the range of 250000 to 1 million …
Alternative cleavage and polyadenylation: the long and short of it
Cleavage and polyadenylation (C/P) of nascent transcripts is essential for maturation of the
3′ ends of most eukaryotic mRNAs. Over the past three decades, biochemical studies have …
3′ ends of most eukaryotic mRNAs. Over the past three decades, biochemical studies have …
Cleavage and polyadenylation: ending the message expands gene regulation
Cleavage and polyadenylation (pA) is a fundamental step that is required for the maturation
of primary protein encoding transcripts into functional mRNAs that can be exported from the …
of primary protein encoding transcripts into functional mRNAs that can be exported from the …
3′ UTR shortening represses tumor-suppressor genes in trans by disrupting ceRNA crosstalk
Widespread mRNA 3′ UTR shortening through alternative polyadenylation promotes tumor
growth in vivo. A prevailing hypothesis is that it induces proto-oncogene expression in cis …
growth in vivo. A prevailing hypothesis is that it induces proto-oncogene expression in cis …
Dysregulation of the basal RNA polymerase transcription apparatus in cancer
Mutations that directly affect transcription by RNA polymerases rank among the most central
mediators of malignant transformation, but the frequency of new anticancer drugs that …
mediators of malignant transformation, but the frequency of new anticancer drugs that …
[HTML][HTML] DNA methylation regulates alternative polyadenylation via CTCF and the cohesin complex
Dysregulation of DNA methylation and mRNA alternative cleavage and polyadenylation
(APA) are both prevalent in cancer and have been studied as independent processes. We …
(APA) are both prevalent in cancer and have been studied as independent processes. We …
Alternative Polyadenylation: a new frontier in post transcriptional regulation
Polyadenylation of pre-messenger RNA (pre-mRNA) specific sites and termination of their
downstream transcriptions are signaled by unique sequence motif structures such as …
downstream transcriptions are signaled by unique sequence motif structures such as …