Structural components of synaptic plasticity and memory consolidation

CH Bailey, ER Kandel… - Cold Spring Harbor …, 2015 - cshperspectives.cshlp.org
Consolidation of implicit memory in the invertebrate Aplysia and explicit memory in the
mammalian hippocampus are associated with remodeling and growth of preexisting …

Autoimmune seizures and epilepsy

C Geis, J Planagumà, M Carreño, F Graus… - The Journal of clinical …, 2019 - jci.org
The rapid expansion in the number of encephalitis disorders associated with autoantibodies
against neuronal proteins has led to an incremental increase in use of the term “autoimmune …

Synaptic nanomodules underlie the organization and plasticity of spine synapses

M Hruska, N Henderson, SJ Le Marchand, H Jafri… - Nature …, 2018 - nature.com
Experience results in long-lasting changes in dendritic spine size, yet how the molecular
architecture of the synapse responds to plasticity remains poorly understood. Here a …

Synaptic plasticity, dementia and Alzheimer disease

SD Skaper, L Facci, M Zusso… - CNS & Neurological …, 2017 - ingentaconnect.com
Neuroplasticity is not only shaped by learning and memory but is also a mediator of
responses to neuron attrition and injury (compensatory plasticity). As an ongoing process it …

Disrupted surface cross-talk between NMDA and Ephrin-B2 receptors in anti-NMDA encephalitis

L Mikasova, P De Rossi, D Bouchet, F Georges… - Brain, 2012 - academic.oup.com
Autoimmune synaptic encephalitides are recently described human brain diseases leading
to psychiatric and neurological syndromes through inappropriate brain–autoantibody …

Modulatory effects of α7 nAChRs on the immune system and its relevance for CNS disorders

HO Kalkman, D Feuerbach - Cellular and molecular life sciences, 2016 - Springer
The clinical development of selective alpha-7 nicotinic acetylcholine receptor (α7 nAChR)
agonists has hitherto been focused on disorders characterized by cognitive deficits (eg …

Ephrin‐B2 prevents N‐methyl‐D‐aspartate receptor antibody effects on memory and neuroplasticity

J Planagumà, H Haselmann, F Mannara… - Annals of …, 2016 - Wiley Online Library
Objective To demonstrate that ephrin‐B2 (the ligand of EphB2 receptor) antagonizes the
pathogenic effects of patients' N‐methyl‐D‐aspartate receptor (NMDAR) antibodies on …

Metabotropic NMDA receptor function is required for β-amyloid–induced synaptic depression

HW Kessels, S Nabavi, R Malinow - … of the National Academy of Sciences, 2013 - pnas.org
The mechanisms by which β-amyloid (Aβ), a peptide fragment believed to contribute to
Alzheimer's disease, leads to synaptic deficits are not known. Here we find that elevated …

Nanoscale rules governing the organization of glutamate receptors in spine synapses are subunit specific

M Hruska, RE Cain, MB Dalva - Nature Communications, 2022 - nature.com
Heterotetrameric glutamate receptors are essential for the development, function, and
plasticity of spine synapses but how they are organized to achieve this is not known. Here …

NMDA receptor activity in neuropsychiatric disorders

SE Lakhan, M Caro, N Hadzimichalis - Frontiers in psychiatry, 2013 - frontiersin.org
N-Methyl-d-aspartate (NMDA) receptors play a variety of physiologic roles and their proper
signaling is essential for cellular homeostasis. Any disruption in this pathway, leading to …