This Perspective is a continuation of our analysis of US FDA-approved small-molecule drugs
(1938–2012) containing nitrogen heterocycles. In this study we report drug structure and …

Fluorine-containing small molecules have occupied a special position in drug discovery
research. The successful clinical use of fluorinated corticosteroids in the 1950s and …

Fluoroorganic chemistry has become essential in the evolution of many different but
interconnected research fields. These include the development of new materials with a …

Covering: 2008–2013. Previous review: 2008, 25, 475 There are a significant number of
natural product (NP) drugs in development. We review the 100 NP and NP-derived …

Eleven new fluorine-containing FDA-approved drugs have been profiled and details of their
discovery and preparation are discussed. Therapeutic areas include schizophrenia …

Some of the most prominent and promising catalysts in organic synthesis for the requisite
construction of C–C and C–N bonds are palladium (Pd) catalysts, which play a pivotal role in …

Lysophospholipids are a class of bioactive lipid molecules that produce their effects through
various G protein-coupled receptors (GPCRs). Sphingosine 1-phosphate (S1P) is perhaps …

G protein-coupled receptors (GPCRs) are versatile and vital proteins involved in a wide
array of physiological processes and responses, such as sensory perception (eg, vision …

Lysophospholipids are bioactive lipids and can signal through G-protein-coupled receptors
(GPCRs). The best studied lysophospholipids are lysophosphatidic acid (LPA) and …

Fingolimod (Gilenya) received regulatory approval from the US FDA in 2010 as the first-in-
class sphingosine 1-phosphate (S1P) receptor (S1PR) modulator and was the first oral …