Angiogenesis and re-endothelialization in decellularized scaffolds: recent advances and current challenges in tissue engineering

R Mazloomnejad, A Babajani, M Kasravi… - … in Bioengineering and …, 2023‏ - frontiersin.org
Decellularization of tissues and organs has recently become a promising approach in tissue
engineering and regenerative medicine to circumvent the challenges of organ donation and …

[HTML][HTML] Decellularized extracellular matrix-based disease models for drug screening

Z Chen, J Wang, RK Kankala, M Jiang, L Long, W Li… - Materials Today Bio, 2024‏ - Elsevier
In vitro drug screening endeavors to replicate cellular states closely resembling those
encountered in vivo, thereby maximizing the fidelity of drug effects and responses within the …

From waste to wealth: Repurposing slaughterhouse waste for xenotransplantation

RL Khan, AA Khraibi, LF Dumée… - … in Bioengineering and …, 2023‏ - frontiersin.org
Slaughterhouses produce large quantities of biological waste, and most of these materials
are underutilized. In many published reports, the possibility of repurposing this form of waste …

Peripheral blood derived endothelial colony forming cells as suitable cell source for pre-endothelialization of arterial vascular grafts under dynamic flow conditions

X Kraus, E van de Flierdt, J Renzelmann, S Thoms… - Microvascular …, 2022‏ - Elsevier
In regenerative medicine, autologous peripheral blood derived endothelial colony forming
cells (PB-derived ECFC) represent a promising source of endothelial cells (EC) for pre …

Multi-Omics Profiling of Human Endothelial Cells from the Coronary Artery and Internal Thoracic Artery Reveals Molecular but Not Functional Heterogeneity

A Frolov, A Lobov, M Kabilov, B Zainullina… - International Journal of …, 2023‏ - mdpi.com
Major adverse cardiovascular events occurring upon coronary artery bypass graft surgery
are typically accompanied by endothelial dysfunction. Total arterial revascularisation, which …

Decellularized vascularized bone grafts as therapeutic solution for bone reconstruction: A mechanical evaluation

U Heller, R Evrard, B Lengelé, T Schubert, N Kadlub… - Plos one, 2023‏ - journals.plos.org
Introduction Large bone defects are challenging for surgeons. Available reimplanted bone
substitutes can't properly restore optimal function along and long term osteointegration of the …

New Insights and Advanced Strategies for In Vitro Construction of Vascularized Tissue Engineering

J Liang, J Zhao, Y Chen, B Li, Y Li, F Lu… - Tissue Engineering Part …, 2023‏ - liebertpub.com
Inadequate vascularization is a significant barrier to clinical application of large-volume
tissue engineered grafts. In contrast to in vivo vascularization, in vitro prevascularization …

Solid fraction determines stiffness and viscosity in decellularized pancreatic tissues

J Snellings, E Keshi, P Tang, A Daneshgar… - Biomaterials …, 2022‏ - Elsevier
The role of extracellular matrix (ECM) composition and turnover in mechano-signaling and
the metamorphic fate of cells seeded into decellularized tissue can be elucidated by recent …

Decellularization of porcine carotid arteries: From the vessel to the high-quality scaffold in five hours

MS Massaro, P Kochová, R Pálek… - … in Bioengineering and …, 2022‏ - frontiersin.org
The use of biologically derived vessels as small-diameter vascular grafts in vascular
diseases is currently intensely studied. Vessel decellularization provides a biocompatible …

Vascular organs-on-chip made with patient-derived endothelial cells: technologies to transform drug discovery and disease modeling

CP Whitworth, WJ Polacheck - Expert Opinion on Drug Discovery, 2024‏ - Taylor & Francis
Introduction Vascular diseases impart a tremendous burden on healthcare systems in the
United States and across the world. Efforts to improve therapeutic interventions are hindered …