Although classically known as an endocrine signal produced by the ovary, 17β-estradiol (E
2) is also a neurosteroid produced in neurons and astrocytes in the brain of many different …

Hormones regulate homeostasis by communicating through the bloodstream to the body's
organs, including the brain. As homeostatic regulators of brain function, some hormones …

Psychiatric disorders are frequently encountered in many neurological disorders, such as
Alzheimer's and Parkinson diseases along with epilepsy, migraine, essential tremors, and …

Neurodegenerative diseases are conventionally demarcated as disorders with selective loss
of neurons. Conventional as well as newer molecules have been tested but they offer just …

The endogenous opioid system consists of 3 families of opioid peptides, ß-endorphin,
enkephalins, and dynorphins, and 3 families of receptors, μ (MOR), δ (, DOR), and κ (KOR) …

Alzheimer's disease (AD) is a highly prevalent neurodegenerative condition that has
devastating effects on individuals, often resulting in dementia. AD is primarily defined by the …

We have developed a versatile new class of genetically encoded fluorescent biosensor
based on reversible exchange of the heterodimeric partners of green and red dimerization …

Leading neurodegenerative diseases Alzheimer's disease (AD) and Parkinson's disease
(PD) are characterized by the impairment of memory and motor functions, respectively …

The word dementia describes a class of heterogeneous diseases which etiopathogenetic
mechanisms are not well understood. There are different types of dementia, among which …

Abstract 17β-estradiol (E2) has been implicated to play a critical role in neuroprotection,
synaptic plasticity, and cognitive function. Classically, the role of gonadal-derived E2 in …