Stroke is considered to be an acute cerebrovascular disease, including ischemic stroke and
hemorrhagic stroke. The high incidence and poor prognosis of stroke suggest that it is a …

Exposure to radiation during the treatment of CNS tumors leads to detrimental damage of
the blood brain barrier (BBB) in normal tissue. Effects are characterized by leakage of the …

Abstract Silent information regulator 1 (SIRT1), a histone deacetylase, has been suggested
to be effective in ischemic brain diseases. Salvianolic acid B (SalB) is a polyphenolic and …

The pathophysiological mechanisms leading to neuronal injury in middle cerebral artery
occlusion (MCAO) model of cerebral stroke are complex and multifactorial that form the …

The ischemic cascade is initiated in the hypoperfused region of the brain that leads to
neuronal cell death. Identification of multi-target inhibitor against prominent molecular …

Oxidative stress is the common underlying mechanism of damage in ischemic stroke.
Therefore, we aimed to evaluate the possible protective effects of polyhydroxylated fullerene …

Fingolimod (FTY720) is a known sphingosine-1-phosphate (S1P) receptor agonist. Several
studies have shown the therapeutic efficacy of FTY720 in neurodegenerative disorders …

Ischemic stroke is one of the leading causes of death and disability. Occlusion and
reperfusion of cerebral blood vessels (ie, ischemia/reperfusion (I/R) injury) generates …

The role of nitric oxide synthases (NOSs) in early blood-brain barrier (BBB) disruption was
determined using a new mouse model of transient focal cerebral ischemia. Ischemia was …

During cerebral ischemia/reperfusion (I/R) injury, oxidative stress and inflammation are
major contributors to disability. Finding compounds that reduce oxidative stress …