Recent strategies for the treatment of cancer, other than just tumor cell killing have been
under intensive development, such as anti-angiogenic therapeutic approach. Angiogenesis …

Nanomedicine greatly improves the efficiency in the delivery of antitumor drugs into the
tumor, but insufficient tumoral penetration impairs the therapeutic efficacy of most …

Cancer is the third leading cause of premature death in sub-Saharan Africa. Cervical cancer
has the highest number of incidences in sub-Saharan Africa due to high HIV prevalence …

Tumor blood vessel formation is a key process for tumor expansion. Tumor vessels are
abnormal and differ from normal vessels in architecture and components. Besides oxygen …

Plants are an important source of chemically diverse natural products that target
microtubules, one of the most successful targets in cancer therapy. Colchicine, paclitaxel …

As the continuation of our work on the development of tubulin inhibitors with potential
anticancer activities, novel bis-substituted aromatic amide dithiocarbamate derivatives were …

The microtubule cytoskeleton plays a critical role in a wide range of cellular activities and
has been shown to be a highly effective target for the treatment of human malignancies …

CA4 is a potent microtubule polymerization inhibitor and vascular disrupting agent.
However, the in vivo efficiency of CA4 is limited owing to its poor pharmacokinetics resulting …

Erianin, a bioactive compound extracted from Dendrobium, a traditional Chinese medicine,
exhibits remarkable anti-cancer properties through diverse molecular mechanisms and has …

Destruction of the established tumour vasculature by a class of compound termed Vascular
Disrupting Agents (VDAs) is showing considerable promise as a viable approach for the …