[HTML][HTML] Neoadjuvant targeted therapy in resectable NSCLC: current and future perspectives

JM Lee, CJ McNamee, E Toloza, MV Negrao… - Journal of Thoracic …, 2023 - Elsevier
The standard of care (SoC) for medically operable patients with early-stage (stages I–IIIB)
NSCLC is surgery combined with (neo) adjuvant systemic therapy for patients with stages II …

[HTML][HTML] Genomic map** of metastatic organotropism in lung adenocarcinoma

HB Lengel, B Mastrogiacomo, JG Connolly, KS Tan… - Cancer Cell, 2023 - cell.com
Summary We analyzed 2,532 lung adenocarcinomas (LUAD) to identify the
clinicopathological and genomic features associated with metastasis, metastatic burden …

Does major pathological response after neoadjuvant Immunotherapy in resectable nonsmall-cell lung cancers predict prognosis? A systematic review and meta …

Y Chen, J Qin, Y Wu, Q Lin, J Wang… - … Journal of Surgery, 2023 - journals.lww.com
Objective: Overall survival is the gold-standard outcome measure for phase 3 trials, but the
need for a long follow-up period can delay the translation of potentially effective treatment to …

[HTML][HTML] Association of pathologic complete response and long-term survival outcomes among patients treated with neoadjuvant chemotherapy or chemoradiotherapy …

S Rosner, C Liu, PM Forde, C Hu - JTO clinical and research reports, 2022 - Elsevier
Introduction Increased efforts to optimize outcomes for early stage NSCLC through the
investigation of novel perioperative treatment strategies are ongoing. An emerging question …

Pathological response in resectable non–small cell lung cancer: a systematic literature review and meta-analysis

NA Waser, M Quintana, B Schweikert… - JNCI Cancer …, 2024 - academic.oup.com
Background Surrogate endpoints for overall survival in patients with resectable non–small
cell lung cancer receiving neoadjuvant therapy are needed to provide earlier treatment …

Morbidity and mortality of lobectomy or pneumonectomy after neoadjuvant treatment: an analysis from the ESTS database

A Brunelli, G Rocco, Z Szanto… - European Journal of …, 2020 - academic.oup.com
OBJECTIVES To evaluate the postoperative complications and 30-day mortality rates
associated with neoadjuvant chemotherapy before major anatomic lung resections …

Cost-effectiveness of neoadjuvant pembrolizumab plus chemotherapy with adjuvant pembrolizumab for early-stage non-small cell lung cancer in the United States

W Tian, L Niu, Z Wang, R Lu, G **ao, F Deng… - Frontiers in …, 2023 - frontiersin.org
Introduction Perioperative (neoadjuvant and adjuvant) pembrolizumab has shown favorable
efficacy in patients with early-stage non-small cell lung cancer (NSCLC). This study aims to …

[HTML][HTML] Canadian consensus recommendations for the management of operable stage II/III non-small-cell lung cancer: results of a modified Delphi process

J Tankel, J Spicer, Q Chu, PO Fiset, B Kidane… - Current …, 2023 - mdpi.com
The treatment paradigm for patients with stage II/III non-small-cell lung cancer (NSCLC) is
rapidly evolving. We performed a modified Delphi process culminating at the Early-stage …

Neoadjuvant approaches in hepatocellular carcinoma: there's no time like the present

JW Franses, AX Zhu - Clinical Cancer Research, 2022 - aacrjournals.org
Hepatocellular carcinoma remains a lethal malignancy and is an increasingly common
cause of cancer death worldwide. Curative-intent surgical resection remains the standard of …

Surgery after neoadjuvant immunotherapy in patients with resectable non-small cell lung cancer

C Huynh, LA Walsh, JD Spicer - Translational Lung Cancer …, 2021 - pmc.ncbi.nlm.nih.gov
Surgery is the standard of care for patients with operable non-small cell lung cancer
(NSCLC). However, as a single modality, surgery for early stage or locally advanced NSCLC …