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Antibodies to combat viral infections: development strategies and progress
Monoclonal antibodies (mAbs) are appealing as potential therapeutics and prophylactics for
viral infections owing to characteristics such as their high specificity and their ability to …
viral infections owing to characteristics such as their high specificity and their ability to …
Development of therapeutic antibodies for the treatment of diseases
It has been more than three decades since the first monoclonal antibody was approved by
the United States Food and Drug Administration (US FDA) in 1986, and during this time …
the United States Food and Drug Administration (US FDA) in 1986, and during this time …
Convergent antibody responses to SARS-CoV-2 in convalescent individuals
During the coronavirus disease-2019 (COVID-19) pandemic, severe acute respiratory
syndrome-related coronavirus-2 (SARS-CoV-2) has led to the infection of millions of people …
syndrome-related coronavirus-2 (SARS-CoV-2) has led to the infection of millions of people …
[HTML][HTML] Affinity maturation of SARS-CoV-2 neutralizing antibodies confers potency, breadth, and resilience to viral escape mutations
Antibodies elicited by infection accumulate somatic mutations in germinal centers that can
increase affinity for cognate antigens. We analyzed 6 independent groups of clonally related …
increase affinity for cognate antigens. We analyzed 6 independent groups of clonally related …
Enhanced SARS-CoV-2 neutralization by dimeric IgA
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus that causes
coronavirus disease 2019 (COVID-19), primarily infects cells at mucosal surfaces. Serum …
coronavirus disease 2019 (COVID-19), primarily infects cells at mucosal surfaces. Serum …
[HTML][HTML] Human neutralizing antibodies elicited by SARS-CoV-2 infection
Abstract The coronavirus disease 2019 (COVID-19) pandemic caused by severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) presents a global health emergency that …
respiratory syndrome coronavirus 2 (SARS-CoV-2) presents a global health emergency that …
[HTML][HTML] Antibodies from primary humoral responses modulate the recruitment of naive B cells during secondary responses
JMJ Tas, JH Koo, YC Lin, Z ** of B cell receptor sequences to antigen specificity
B cell receptor (BCR) sequencing is a powerful tool for interrogating immune responses to
infection and vaccination, but it provides limited information about the antigen specificity of …
infection and vaccination, but it provides limited information about the antigen specificity of …
Sustained HIV remission after allogeneic hematopoietic stem cell transplantation with wild-type CCR5 donor cells
HIV cure has been reported for five individuals who underwent allogeneic hematopoietic
stem cell transplantation (allo-HSCT) with cells from CCR5Δ32 homozygous donors. By …
stem cell transplantation (allo-HSCT) with cells from CCR5Δ32 homozygous donors. By …
Defining HPV-specific B cell responses in patients with head and neck cancer
Tumours often contain B cells and plasma cells but the antigen specificity of these
intratumoral B cells is not well understood,,,,,,–. Here we show that human papillomavirus …
intratumoral B cells is not well understood,,,,,,–. Here we show that human papillomavirus …