Copper: toxicological relevance and mechanisms

LM Gaetke, HS Chow-Johnson, CK Chow - Archives of toxicology, 2014 - Springer
Copper (Cu) is a vital mineral essential for many biological processes. The vast majority of
all Cu in healthy humans is associated with enzyme prosthetic groups or bound to proteins …

Study on toxicity effects of environmental pollutants based on metabolomics: A review

L Liu, Q Wu, X Miao, T Fan, Z Meng, X Chen, W Zhu - Chemosphere, 2022 - Elsevier
In the past few decades, the toxic effects of environmental pollutants on non-target
organisms have received more and more attention. As a new omics technology …

Combined effects of polystyrene microplastics and natural organic matter on the accumulation and toxicity of copper in zebrafish

R Qiao, K Lu, Y Deng, H Ren, Y Zhang - Science of the Total Environment, 2019 - Elsevier
As emerging contaminants, microplastics (MPs) are predicted to act as vectors for other
contaminants and their combined effects are largely unknown. In this study, the combined …

1H NMR and GC-MS Based Metabolomics Reveal Defense and Detoxification Mechanism of Cucumber Plant under Nano-Cu Stress

L Zhao, Y Huang, J Hu, H Zhou… - … science & technology, 2016 - ACS Publications
Because copper nanoparticles are being increasingly used in agriculture as pesticides, it is
important to assess their potential implications for agriculture. Concerns have been raised …

[HTML][HTML] Approaches to integrating metabolomics and multi-omics data: a primer

T Jendoubi - Metabolites, 2021 - mdpi.com
Metabolomics deals with multiple and complex chemical reactions within living organisms
and how these are influenced by external or internal perturbations. It lies at the heart of …

Copper signaling in the brain and beyond

CM Ackerman, CJ Chang - Journal of Biological Chemistry, 2018 - jbc.org
Transition metals have been recognized and studied primarily in the context of their
essential roles as structural and metabolic cofactors for biomolecules that compose living …

Metabolomics and fish nutrition: a review in the context of sustainable feed development

S Roques, C Deborde, N Richard… - Reviews in …, 2020 - Wiley Online Library
Aquaculture is facing a strategic challenge to improve feed suitability and support the global
increase in fish production. Improvements in diet formulation for sustainable nutritional …

The metabolomic window into hepatobiliary disease

D Beyoğlu, JR Idle - Journal of hepatology, 2013 - Elsevier
The emergent discipline of metabolomics has attracted considerable research effort in
hepatology. Here we review the metabolomic data for non-alcoholic fatty liver disease …

[HTML][HTML] Effects of copper exposure on oxidative stress, apoptosis, endoplasmic reticulum stress, autophagy and immune response in different tissues of Chinese …

W Feng, S Su, C Song, F Yu, J Zhou, J Li, R Jia, P Xu… - Antioxidants, 2022 - mdpi.com
High concentrations of copper (Cu2+) pose a great threat to aquatic animals. However, the
mechanisms underlying the response of crustaceans to Cu2+ exposure have not been well …

Insights into the mechanisms underlying mercury-induced oxidative stress in gills of wild fish (Liza aurata) combining 1H NMR metabolomics and conventional …

T Cappello, F Brandão, S Guilherme, MA Santos… - Science of the Total …, 2016 - Elsevier
Oxidative stress has been described as a key pathway to initiate mercury (Hg) toxicity in fish.
However, the mechanisms underlying Hg-induced oxidative stress in fish still need to be …