Cells are essential to understanding health and disease, yet traditional models fall short of
modeling and simulating their function and behavior. Advances in AI and omics offer …

A series of monoclonal antibodies with therapeutic potential against cancer have been
generated and developed. Ninety-one are currently used in the clinics, either alone or in …

Background A recent paper has revealed a novel cell death pathway, cuproptosis, a
programmed cell death based on copper. This study aimed to evaluate the pan-cancer …

We present a human miRNA tissue atlas by determining the abundance of 1997 miRNAs in
61 tissue biopsies of different organs from two individuals collected post-mortem. One …

Tissues are complex environments where different cell types are in constant interaction with
each other and with non-cellular components. Preserving the spatial context during …

Long noncoding RNAs (lncRNAs) have emerged as regulators of diverse biological
processes. Here, we describe the initial functional analysis of a poorly characterized human …

The extracellular matrix (ECM) is a fundamental component of multicellular organisms that
provides mechanical and chemical cues that orchestrate cellular and tissue organization …

Caspases are proteases with a well-defined role in apoptosis. However, increasing
evidence indicates multiple functions of caspases outside apoptosis. Caspase-1 and …

To gain a better understanding of the complexity of gene expression in normal and diseased
tissues it is important to account for the spatial context and identity of cells in situ. State-of …

Small non-coding RNAs (sncRNAs) are pervasive regulators of physiological and
pathological processes. We previously developed the human miRNA Tissue Atlas, detailing …