Cancer is now viewed as a stem cell disease. There is still no consensus on the metabolic
characteristics of cancer stem cells, with several studies indicating that they are mainly …

Phenotypic and functional heterogeneity is one of the most relevant features of cancer cells
within different tumor types and is responsible for treatment failure. Cancer stem cells …

Malignant tumors contain heterogeneous populations of cells in various states of
proliferation and differentiation. The presence of cancer stem or initiating cells is a well …

Altered metabolism in cancer cells is pivotal for tumor growth, most notably by providing
energy, reducing equivalents and building blocks while several metabolites exert a …

Despite a continuing debate about the existence of cancer stem cells (CSCs), recent
discoveries have provided further support for their existence and their roles in drug …

Previous studies have shown that mitochondria play core roles in not only cancer stem cell
(CSC) metabolism but also the regulation of CSC stemness maintenance and differentiation …

The role of fatty acid metabolism, including both anabolic and catabolic reactions in cancer
has gained increasing attention in recent years. Many studies have shown that aberrant …

Therapy resistance represents a clinical challenge for advanced non-small cell lung cancer
(NSCLC), which still remains an incurable disease. There is growing evidence that cancer …

Cancer stem cells (CSCs) are subpopulation of cells which have been demonstrated in a
variety of cancer models and involved in cancer initiation, progression, and development …

Cancer-initiating cells (CICs) are responsible for tumor initiation, progression, and
therapeutic resistance; moreover, redox homeostasis is important in regulating cancer …