The same genetic variant found in different individuals can cause a range of diverse
phenotypes, from no discernible clinical phenotype to severe disease, even among related …

Cystic fibrosis (CF) is the most common life-threatening monogenic disease afflicting
Caucasian people. It affects the respiratory, gastrointestinal, glandular and reproductive …

Coding variants represent many of the strongest associations between genotype and
phenotype; however, they exhibit inter-individual differences in effect, termed 'variable …

Gene expression is an essential step in the translation of genotypes into phenotypes.
However, little is known about the transcriptome architecture and the underlying genetic …

Intellectual disability (ID) is a clinically and genetically heterogeneous disorder, affecting 1–
3% of the general population. Although research into the genetic causes of ID has recently …

Genes encode components of coevolved and interconnected networks. The effect of
genotype on phenotype therefore depends on genotypic context through gene interactions …

Genotype-phenotype relationships can vary extensively among members of a species. One
cause of this variation is circuit diversification, the alteration of gene regulatory relationships …

Over the last 20 years, studies of Caenorhabditis elegans natural diversity have
demonstrated the power of quantitative genetic approaches to reveal the evolutionary …

What makes a gene essential for cellular survival? In model organisms, such as budding
yeast, systematic gene deletion studies have revealed that paralog genes are less likely to …

CRISPR/Cas9 has emerged as one of the most popular genome editing tools due to its
simple design and high efficiency in multiple species. Myostatin (MSTN) negatively …