Progresses and prospects of neuroprotective agents-loaded nanoparticles and biomimetic material in ischemic stroke

J Chen, J **, K Li, L Shi, X Wen, F Fang - Frontiers in Cellular …, 2022 - frontiersin.org
Ischemic stroke remains the leading cause of death and disability, while the main
mechanisms of dominant neurological damage in stroke contain excitotoxicity, oxidative …

Recent advances in chemically engineered nanostructures impact on ischemic stroke treatment

G Sri Kanaka Durga Vijayalakshmi, N Puvvada - ACS omega, 2023 - ACS Publications
Stroke is a serious public health problem that raises expenses for society and causes long-
term impairment and death. However, due to restricted blood–brain barrier (BBB) …

Protein kinase C-delta inhibition protects blood-brain barrier from sepsis-induced vascular damage

Y Tang, F Soroush, S Sun, E Liverani… - Journal of …, 2018 - Springer
Background Neuroinflammation often develops in sepsis leading to activation of cerebral
endothelium, increased permeability of the blood-brain barrier (BBB), and neutrophil …

[HTML][HTML] Neuroprotection of hydroxysafflor yellow A in experimental cerebral ischemia/reperfusion injury via metabolic inhibition of phenylalanine and mitochondrial …

S Chen, M Sun, X Zhao, Z Yang… - Molecular …, 2019 - spandidos-publications.com
Stroke is the second most frequent cause of mortality, resulting in a huge societal burden
worldwide. Timely reperfusion is the most effective therapy; however, it is difficult to prevent …

Nanocarriers for stroke therapy: advances and obstacles in translating animal studies

SA Alkaff, K Radhakrishnan… - International journal …, 2020 - Taylor & Francis
The technology of drug delivery systems (DDS) has expanded into many applications, such
as for treating neurological disorders. Nanoparticle DDS offer a unique strategy for targeted …

Burns impair blood-brain barrier and mesenchymal stem cells can reverse the process in mice

J Yang, K Ma, C Zhang, Y Liu, F Liang, W Hu… - Frontiers in …, 2020 - frontiersin.org
Neurological syndromes are observed in numerous patients who suffer burns, which add to
the economic burden of societies and families. Recent studies have implied that blood–brain …

Post-ischemic administration of dopamine D2 receptor agonist reduces cell death by activating mitochondrial pathway following ischemic stroke

P Kaushik, M Ali, H Tabassum, S Parvez - Life Sciences, 2020 - Elsevier
Aims Cerebral ischemic stroke leads to mitochondrial alterations which are key factors for
initiation of various cascades resulting in neuronal damage. Dopamine D2 receptor (D2R) …

The effect of sevoflurane and fullerenol C 60 on the liver and kidney in lower extremity ischemia-reperfusion injury in mice with streptozocin-induced diabetes

N Şengel, A Küçük, Ç Özdemir, ŞC Sezen… - International Journal …, 2023 - Taylor & Francis
Objective This study aimed to demonstrate whether fullerenol C60, sevoflurane anesthesia,
or a combination of both had protective effects on the liver and kidneys in lower extremity …

Insight on bacterial newborn meningitis using a neurovascular-unit-on-a-chip

R Rauti, S Navok, D Biran, K Tadmor… - Microbiology …, 2023 - Am Soc Microbiol
Understanding the pathogenesis of bacterial infections is critical for combatting them. For
some infections, animal models are inadequate and functional genomic studies are not …

Wielding the double‐edged sword of inflammation: building biomaterial‐based strategies for immunomodulation in ischemic stroke treatment

N Letko Khait, E Ho, MS Shoichet - Advanced Functional …, 2021 - Wiley Online Library
Stroke is a leading cause of disability with no current treatment to regenerate lost brain
tissue. Innovative preclinical and clinical trials have attempted to improve stroke recovery by …