Our ancestors acquired morphological, cognitive and metabolic modifications that enabled
humans to colonize diverse habitats, develop extraordinary technologies and reshape the …

For decades, insight into fundamental principles of human biology and disease has been
obtained primarily by experiments in animal models. While this has allowed researchers to …

The intimate relationship between the epithelium and immune system is crucial for
maintaining tissue homeostasis, with perturbations therein linked to autoimmune disease …

Deciphering universal gene regulatory mechanisms in diverse organisms holds great
potential for advancing our knowledge of fundamental life processes and facilitating clinical …

Tumours can obtain nutrients and oxygen required to progress and metastasize through the
blood supply. Inducing angiogenesis involves the sprouting of established vessel beds and …

Tissue regeneration after damage is generally thought to involve the mobilization of adult
stem cells that divide and differentiate into progressively specialized progeny. However …

Most organs have tissue-resident immune cells. Human organoids lack these immune cells,
which limits their utility in modeling many normal and disease processes. Here, we describe …

Human skin uses millions of hairs and glands distributed across the body surface to function
as an external barrier, thermoregulator and stimuli sensor. The large-scale generation of …

The gastrointestinal tract is a multi-organ system crucial for efficient nutrient uptake and
barrier immunity. Advances in genomics and a surge in gastrointestinal diseases, has …

As an emerging sequencing technology, single-cell RNA sequencing (scRNA-Seq) has
become a powerful tool for describing cell subpopulation classification and cell …