Proteins are nature's primary building blocks for the construction of sophisticated molecular
machines and dynamic materials, ranging from protein complexes such as photosystem II …

The structure and integrity of telomeres are essential for genome stability. Telomere
dysregulation can lead to cell death, cell senescence, or abnormal cell proliferation. The …

The mechanisms that maintain the stability of chromosome ends have broad impact on
genome integrity in all eukaryotes. Budding yeast is a premier organism for telomere …

Telomerase is the enzyme responsible for maintenance of the length of telomeres by
addition of guanine-rich repetitive sequences. Telomerase activity is exhibited in gametes …

Human telomerase contains a 451 nt RNA (hTR) and several proteins, including a
specialized reverse transcriptase (hTERT). The 5′ half of hTR comprises the pseudoknot …

In contrast to the fairly reliable and complete annotation of the protein coding genes in the
human genome, comparable information is lacking for noncoding RNAs (ncRNAs). We …

Telomerase is a specialized DNA polymerase that extends the 3′ ends of eukaryotic linear
chromosomes, a process required for genomic stability and cell viability. Here we present …

Telomeres are the physical ends of eukaryotic linear chromosomes. Telomeres form special
structures that cap chromosome ends to prevent degradation by nucleolytic attack and to …

Maintenance of telomeres by the enzyme telomerase is essential for genomic stability and
cell viability in ciliates, vertebrates and yeast. The minimal components of telomerase …

Telomerase is a reverse transcriptase specialized in the addition of telomeric DNA repeats
onto the ends of chromosomes. Telomere extension offsets the loss of telomeric repeats …