Malaria: progress, perils, and prospects for eradication
There are still approximately 500 million cases of malaria and 1 million deaths from malaria
each year. Yet recently, malaria incidence has been dramatically reduced in some parts of …
each year. Yet recently, malaria incidence has been dramatically reduced in some parts of …
Ensuring quality and access for malaria diagnosis: how can it be achieved?
D Bell, C Wongsrichanalai, JW Barnwell - Nature Reviews Microbiology, 2006 - nature.com
The replacement of conventional antimalarial drugs with high-cost, artemisinin-based
alternatives has created a gap in the successful management of malaria. This gap reflects …
alternatives has created a gap in the successful management of malaria. This gap reflects …
A comprehensive evaluation of rodent malaria parasite genomes and gene expression
Background Rodent malaria parasites (RMP) are used extensively as models of human
malaria. Draft RMP genomes have been published for Plasmodium yoelii, P. berghei ANKA …
malaria. Draft RMP genomes have been published for Plasmodium yoelii, P. berghei ANKA …
Genome sequence of Babesia bovis and comparative analysis of apicomplexan hemoprotozoa
KA Brayton, AOT Lau, DR Herndon, L Hannick… - PLoS …, 2007 - journals.plos.org
Babesia bovis is an apicomplexan tick-transmitted pathogen of cattle imposing a global risk
and severe constraints to livestock health and economic development. The complete …
and severe constraints to livestock health and economic development. The complete …
Computational prediction of host-pathogen protein–protein interactions
Motivation: Infectious diseases such as malaria result in millions of deaths each year. An
important aspect of any host-pathogen system is the mechanism by which a pathogen can …
important aspect of any host-pathogen system is the mechanism by which a pathogen can …
Whole-genome analysis of mRNA decay in Plasmodium falciparumreveals a global lengthening of mRNA half-life during the intra-erythrocytic development cycle
JL Shock, KF Fischer, JL DeRisi - Genome biology, 2007 - Springer
Background: The rate of mRNA decay is an essential element of post-transcriptional
regulation in all organisms. Previously, studies in several organisms found that the specific …
regulation in all organisms. Previously, studies in several organisms found that the specific …
Hijacking of host cellular functions by the Apicomplexa
F Plattner, D Soldati-Favre - Annu. Rev. Microbiol., 2008 - annualreviews.org
Intracellular pathogens such as viruses and bacteria subvert all the major cellular functions
of their hosts. Targeted host processes include protein synthesis, membrane trafficking …
of their hosts. Targeted host processes include protein synthesis, membrane trafficking …
[HTML][HTML] Post-genomic vaccine development
D Serruto, R Rappuoli - FEBS letters, 2006 - Elsevier
For over a century, vaccines were developed according to Pasteur's principles of isolating,
inactivating and injecting the causative agent of an infectious disease. The availability of a …
inactivating and injecting the causative agent of an infectious disease. The availability of a …
The Hsp40 proteins of Plasmodium falciparum and other apicomplexa: regulating chaperone power in the parasite and the host
M Botha, ER Pesce, GL Blatch - The international journal of biochemistry & …, 2007 - Elsevier
Extensive structural and functional remodelling of Plasmodium falciparum (malaria)-infected
erythrocytes follows the export of a range of proteins of parasite origin (exportome) across …
erythrocytes follows the export of a range of proteins of parasite origin (exportome) across …
Melatonin and IP3-induced Ca2+ release from intracellular stores in the malaria parasite Plasmodium falciparum within infected red blood cells
IP 3-dependent Ca 2+ signaling controls a myriad of cellular processes in higher eukaryotes
and similar signaling pathways are evolutionarily conserved in Plasmodium, the intracellular …
and similar signaling pathways are evolutionarily conserved in Plasmodium, the intracellular …