MDS clinical diagnostic criteria for Parkinson's disease

RB Postuma, D Berg, M Stern, W Poewe… - Movement …, 2015 - Wiley Online Library
This document presents the Movement Disorder Society Clinical Diagnostic Criteria for
Parkinson's disease (PD). The Movement Disorder Society PD Criteria are intended for use …

The prevalence of Parkinson's disease: a systematic review and meta‐analysis

T Pringsheim, N Jette, A Frolkis… - Movement …, 2014 - Wiley Online Library
Parkinson's Disease (PD) is a common neurodegenerative disorder. We sought to
synthesize studies on the prevalence of PD to obtain an overall view of how the prevalence …

CD4+ T cells contribute to neurodegeneration in Lewy body dementia

D Gate, E Tapp, O Leventhal, M Shahid, TJ Nonninger… - Science, 2021 - science.org
Recent studies indicate that the adaptive immune system plays a role in Lewy body
dementia (LBD). However, the mechanism regulating T cell brain homing in LBD is …

Diagnostic criteria for Parkinson's disease: from James Parkinson to the concept of prodromal disease

L Marsili, G Rizzo, C Colosimo - Frontiers in neurology, 2018 - frontiersin.org
The diagnosis of Parkinson's disease (PD) is based on clinical features and differently to the
common opinion that detecting this condition is easy, seminal clinicopathological studies …

iPSC-derived neurons from GBA1-associated Parkinson's disease patients show autophagic defects and impaired calcium homeostasis

DC Schöndorf, M Aureli, FE McAllister… - Nature …, 2014 - nature.com
Mutations in the acid β-glucocerebrosidase (GBA1) gene, responsible for the lysosomal
storage disorder Gaucher's disease (GD), are the strongest genetic risk factor for Parkinson's …

Epidemiology of Parkinson's disease

OB Tysnes, A Storstein - Journal of neural transmission, 2017 - Springer
Parkinson's disease (PD) affects 1–2 per 1000 of the population at any time. PD prevalence
is increasing with age and PD affects 1% of the population above 60 years. The main …

The prevalence and incidence of dementia with Lewy bodies: a systematic review of population and clinical studies

SAV Jones, JT O'brien - Psychological medicine, 2014 - cambridge.org
BackgroundDementia with Lewy bodies (DLB) is increasingly recognized as a common
cause of dementia in older people. However, its true frequency remains unclear, with …

Epidemiology of Parkinson's disease

LML De Lau, MMB Breteler - The Lancet Neurology, 2006 - thelancet.com
The causes of Parkinson's disease (PD), the second most common neurodegenerative
disorder, are still largely unknown. Current thinking is that major gene mutations cause only …

Neuropsychological and clinical heterogeneity of cognitive impairment and dementia in patients with Parkinson's disease

AA Kehagia, RA Barker, TW Robbins - The Lancet Neurology, 2010 - thelancet.com
Cognitive impairment in patients with Parkinson's disease is gaining increased clinical
significance owing to the relative success of therapeutic approaches to the motor symptoms …

The spectrum of nonmotor symptoms in early Parkinson disease

TK Khoo, AJ Yarnall, GW Duncan, S Coleman… - Neurology, 2013 - AAN Enterprises
Objective: Nonmotor symptoms (NMS) are common in patients with established Parkinson
disease (PD) but their frequency in early PD has not been extensively studied. Our aim was …