Opioids continue to be of use for the treatment of pain. Most clinically used analgesics target
the μ opioid receptor whose activation results in adverse effects like respiratory depression …

Mu-opioid receptor (µOR) agonists such as fentanyl have long been used for pain
management, but are considered a major public health concern owing to their adverse side …

Respiratory depression is the proximal cause of death in opioid overdose, yet the
mechanisms underlying this potentially fatal outcome are not well understood. The goal of …

The µ-opioid receptor (µOR) is a well-established target for analgesia, yet conventional
opioid receptor agonists cause serious adverse effects, notably addiction and respiratory …

G-protein-coupled receptors (GPCRs) play pivotal roles in various physiological processes.
These receptors are activated to different extents by diverse orthosteric ligands and …

Allosteric modulators of G-protein-coupled receptors (GPCRs) enhance signaling by binding
to GPCRs concurrently with their orthosteric ligands, offering a novel approach to overcome …

The μ-opioid receptor regulates reward derived from both drug use and natural experiences,
including social interaction, through actions in the nucleus accumbens. Here, we studied …

The mu opioid receptor (μOR) is a target for clinically used analgesics. However, adverse
effects, such as respiratory depression and physical dependence, necessitate the …

The US faces an unprecedented surge in fatal drug overdoses. Naloxone, the only antidote
for opiate overdose, competes at the mu opioid receptor (μOR) orthosteric site. Naloxone …

Several neurochemical systems converge in the prefrontal cortex (PFC) to regulate cognitive
and motivated behaviors. A rich network of endogenous opioid peptides and receptors …